Many articles mention that the carrageenan induced edema in rats, but the original article mentions that the lambda fraction is active, and in our laboratory we have no lambda fraction and urges us to begin an experiment....
We realize the model of paw edema induced by carrageenan according to the method of Winter et al. (1962) with an intraplantar injection of 0,1 mL / paw of carrageenin solution of 1% w / v on the right hind paw. The phlogistic agent (carrageenan) will be prepared at a concentration of 1% (1% Cg), utilizing saline (0.9% NaCl) as diluent. Carrageenan purchased fromSigma Chemical Co., St. Louis, MO, USA).
Carrageenan lambda was much more potent to induce rat paw oedema than carrageenan kappa. Moreover, paw oedema was of lesser intensity. This was the reason to continue using carrageenan lambda over the years in the lab.
The three main commercially available carrageenans are lamba, iota and kappa. In 2010 Silva et al did a study looking at paw edema comparing these three carrageenan compounds (Anticoagulant activity, paw edema and pleurisy induced carrageenan: Action of major types of commercial carrageenans). Although there might be differences between the subtypes, I reckon paw edema should be present with all of them.
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