This research question explores the complex interactions between oral microbes and the oral sensory system. The diversity and function of oral microbial communities play an important role in oral health and disease, and may affect the oral sensory system, including comfort and pain perception, through multiple mechanisms.

Oral microbes can directly or indirectly affect the sensory sensitivity of oral tissues through their metabolites, interactions with host cells, and effects on the immune and nervous systems. Some microbes may trigger oral inflammatory responses, release inflammatory mediators, or cause the occurrence and aggravation of oral pain by affecting the excitability of nerve endings.

A deep understanding of this interaction between oral microbes and the oral sensory system not only helps to reveal the pathogenesis of oral diseases, but also provides a new theoretical basis for the development of personalized treatment strategies targeting microbes. Through advanced molecular biology techniques and neuroscience research, the detailed interaction mechanism between oral microbes and the sensory system can be further explored, providing new ideas and possibilities for improving patients' oral comfort and pain management.

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