Does anyone know or have a breast cancer murine model to study recurrence? I have checked the literature, but did not find relavant references. I am not sure whether it was because there's no good murine model for this or I did not use good keywords.
Thanks for your kind help
You can please refer to the following articles:-
1. Anna Fantozzi and Gerhard Christofori* (2006). Mouse models of breast cancer metastasis. Breast Cancer Research 8:212 doi: 10.1186/bcr1530 (http://www.breast-cancer-research.com/content/8/4/212)
2. Tracy Vargo-Gogola & Jeffrey M. Rosen (2007). Modelling breast cancer: one size does not fit all. Nature Reviews Cancer 7, 659-672. doi:10.1038/nrc2193 (http://www.nature.com/nrc/journal/v7/n9/full/nrc2193.html)
Personally, my mouse model would be a good example of breast cancer recurrence. We study the effect of the pre-irradiation of mammary tissue before the implantation of cancel cells to show how residual cells act in the tissue after radiotherapy and the resulting enhancement of metastasis development. http://www.ncbi.nlm.nih.gov/pubmed/24002607
Some of Mary Helen Barcellos-Hoff publications could also be interesting for you.
4T1 orthotopic model is a good murine breast cancer model for recurrence studies.
Thanks for all of your recommendations. In addition to transgenic mice, I knew that 4T1 might be a good model for this issue. However, does any one have an estimated idea that how long does it take for 4T1 cells to develop recurrence after primary tumor resection? In addition, to what size should we resect it? Once it is visible? We are working on B6 mice basically, so 4T1 might be a good fit. However, it is growing really fast that our intervention might hardly have a chance to see the difference...
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