I am curious to know whether soluble proteins are active in circulation? or they become active after entering the extracellular space? I know it varies from protein to protein but would like to have an overview on this.
Thanks
Vivek
Dear Vivek, as you say it depends on the protein, but it is a known fact that a lot of enzymes preserve their activity when they are isolated from the cellular environment. The interesting question would be if those proteins have the same activity in cell and outside but that, again, depends on the system you are studying.
Thanks, for the answer. I want to know their activity of soluble proteins in vivo.
That probably depends on regulation (e.g. phosphorylation, binding partner etc.), but in general they should not be deactivated only by transport to extracellular space
Hi Vivek,
As you have mentioned the activity of the protein depends on its localization. In addition to localization; post translational modifications, signal peptide cleavage (secretory signals-extracellular proteins) etc also determines their activity..
In in vivo conditions, the extracellular targeted proteins might also have intracellular functions, but it might differ from its extracellular role..
Saravanan K
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