Natural Product Pharmacology

Distinct natural compounds, usually plant-derived secondary metabolites that target pharmacologically relevant pathways. | Contact experts in Natural Product Pharmacology to get answers

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Questions related to Natural Product Pharmacology

Can any one help me in dissolving Albendazole standard drug for wormicidal activity?

Albendazole is insoluble in water. I tried 1% DMSO, 0.5 %Tween 20, in combination of both. Even it is soluble in some acids like formic acid and acetic acid those are toxic for worms. so, I want...

05 May 2014 358 7 View

Can anybody explain how to calculate dose dependent IC50 values for the compound anti-oxidant activity?

See above

05 May 2014 4,107 9 View

What would be correct way to remove chlorophyll from leaves extract?

working on ethanolic extract of plant leaves and appears very dark colour. how can I ensure that the chlorophyll wont interrupt with my compounds in extract?

04 April 2014 8,178 3 View

Are there any standard polysaccharides with phenol rings?

I isolated polysaccharide from a plant and its giving strong fluorescence in UV light, but not giving any quenching with AlCl3 in UV absorption spectrum, I hope it contains a aromatic ring. Apart...

04 April 2014 6,476 3 View

I am trying to detect Phytosterols through LB reagent. However, it needs chloroform extract and I have obtained it in DMSO.

For standard curve, the cholesterol was dissolved in chloroform and then reacted with LB reagent and was fruitful. But when cholesterol was dissolved in acetone and reacted with LB reagent, an...

04 April 2014 8,337 4 View

How do you think scientists working on natural products can fill the gap between drug discovery and application?

A plethora of novel natural products are continuously discovered. Many of them display important bioactive effects, particularly for applications in human medicine, but very few have a...

04 April 2014 3,338 4 View

Where can I find the Indonesian Natural Product Database?

I'm especially looking for biologically active natural products or medicinal herbs and plants. Probably books, journals, CDs, or website? Thank you very much.

03 March 2014 1,227 0 View

How to report standard deviation for IC50 calculation?

We use Graph Pad Prism for IC50 calculations. This program reports standard error for logIC50 but not for the IC50 itself. So my question is, how do you report standard deviation for IC50 with...

03 March 2014 4,033 8 View

Could anyone suggest current literature on Aurasperone B & E?

Literature based on Aurasperones B & E from sponge associated marine fungi would be very helpful.

01 January 2014 4,048 2 View

How do I extract anthraquinones from a plant roots?

I am analysing the phytochemistry for cassia abbreviata, information from literature shows that the major constituents are alkaloids, flavonoids and anthraquinones, so I have to extract the 3...

01 January 2014 7,259 5 View

What quantity and duration of essential oils should be inhaled for relief in psychiatric disorders?

I am interested in research on the therapeutic effects of essential oils in humans and would like to do it in my experiment but I don't have an information on it. Does anyone have any references...

11 November 2013 2,390 1 View

Any suggestion on the presence Saponins in Hexane extract of a herb?

I am a little stumped here. I have repeatedly got a persistent froth from a hexane extract. This is against every other reference I have seen. I need an explanation for this.

11 November 2013 2,544 7 View

What are the important chemical compounds mainly in natural products which are responsible for aging?

We are very new to this aging research project so please suggest me some important molecules which inhibits aging.

10 October 2013 7,950 1 View

What is the mechanism of induction of dyslipidemia in rat model by Triton WR1339?

I want to study the hypolipemic potentials of a medicinal plant.

09 September 2013 9,083 2 View

Therapeutic index limitations for potent, moderate and weak anti HIV agents?

I extracted some phytochemicals and have tested their anti HIV activity calculating their IC50 and therapeutic indices. Now I want to classify them to weak, moderate and potent anti HIV agents. Is...

09 September 2013 816 0 View

What is the difference between the mechanism of action of levamisole and leflunomide?

In the search of some immunomodulatory plant based drugs during a preclinical study involving the immunosuppression by cyclophosphamide followed by treatment of the diseased condition with...

07 July 2013 9,480 2 View

Proton NMR signals of polyketides

Do polyketides have some characteristics of porton NMR singals? For example, terpenes have the characteristics of methyl singlets between 0.5 and 1 ppm? Is there a way that you can tell if a...

07 July 2013 8,984 1 View

Solubility issue of betulinic acid?

I have isolated some betulinic acid from a plant extract, but I can not find a way to dissolve the compound to run NMR. From the literature, people would use pyridine to dissolve it, but it's very...

05 May 2013 7,010 10 View

Is phytochemical testing i.e. total alkaloid, tannins etc applicable to mushrooms sample?

04 April 2013 5,992 5 View

Does gallic acid, ellagic acid, chebulagic acid has protective effect on glutamate toxicity induced neuronal death?

Gallic acid, ellagic acid and chebulagic acid are the major polyphenols from the fruit of Terminalia chebula and it is reported that some polyphenols like baicalein have the neuroprotective effect...

04 April 2013 7,597 0 View

Why is cardamom ground along with sugar in food preparations?

Importance of crystal sugar in Ayurvedic preparations.

03 March 2013 7,932 4 View

How to fix emission and excitation wavelength in fluorescence spectroscopy?

I am working with three different plant species where I have extracted the plant material using four different solvents. How do I fix an excitation or emission wavelength for comparing the three...

03 March 2013 8,729 17 View

Does anyone have any information/references on antiviral properties of Licorice, Glycyrrhiza glabra, root extract.

For example, against rotavirus, herpes simplex, HIV.

02 February 2013 7,697 2 View

How did you prepare the α,β-unsaturated acid chlorides?

I am working on the preparation of licochalcones from coumarins and, upon ring-opening of the latter, I get the α,β-unsaturated stearate.

01 January 2013 974 4 View

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