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Questions related to Disease Models
I am working on the potential of essential oils on an Alzheimer's disease model using neuroblastoma cells SH-SY5Y. How do I dissolve my essential oils into the culture so it would not form a...
07 July 2018 3,734 1 View
My Bifurcation analysis shows that the endemic equilibrium point of my model undergoes the forward bifurcation. I need to understand its implication for the infectious diseases. Thank you.
06 June 2018 6,199 0 View
I am going to work on geriatric sporadic Alzheimer's disease. Tripple transgenic mice model is good for famillial alzheimer's disease but it is not a good model for sporadic alzheimer's.
04 April 2018 2,897 3 View
I'm studying cell survival in primary dopaminergic neurons upon toxin challenge with MPP+ (in vitro Parkinson's Disease model). I want to test whether a range of compounds can reduce dopaminergic...
03 March 2018 5,738 4 View
Several articles suggested that GAPDH might play a role in neurodegenerative diseases such as AD, and potentially interacts with beta amyloid precursor proteins. I am using proteins extracted from...
01 January 2018 629 3 View
Hello everyone, Th1 and Th17 cell play a pathogenic role in mice disease model, while play a protective role in healthy mice. Here I want to ask will it cause inflammation if there are reduced...
10 October 2017 7,329 0 View
Can anyone advise me on the best dopaminergic cell lines? I am particularly interested in finding out more about RCSN-3. What are the pros and cons? Are they difficult/expensive to culture? Would...
07 July 2017 4,505 2 View
which one is more appropriate for inducing AD (ICV injection of amyloid beta), immunization, Morris Water Maze test and hippocampus RNA extraction (RT-PCR)?
05 May 2017 1,501 3 View
We induced Low grade chronic liver failure in rats by thioacetamide 50mg/kg OD intraperitoneally for 14 days (Singh 2014). We are also studying subsequent RENAL INJURY on this low dose . What...
02 February 2017 5,273 0 View
Hi there,I would like to induce some genetic diseases (Freidrichs, Duchenne etc.) in vitro, this is however my first time trying such a thing. Are there reasons to choose shRNA, siRNA over Cas9...
12 December 2016 10,001 2 View
We are currently working with NSG mice which are deficient in complement C5a. This protein is important for our disease model but due to it's short half-life repeated injections would be required...
29 September 2016 5,428 2 View
09 September 2016 7,313 2 View
Devote myself to pre-clinical pharmacological research in vitro and in vivo, especially develop and co-develop monkeys' (NHPs) disease model in different fields.
08 August 2016 6,309 0 View
HI all, I have a animal model that I would like to use for an fMRI experiment. The disease model we use requires a bolus injection of heparin at the start. I'm wondering if I measure the change...
05 May 2016 4,176 1 View
My end goal is to isolate glia and infiltrating lymphocytes from the CNS of my disease model for FACS analysis and adoptive transfer. My hope is to find a method that will keep cells alive through...
05 May 2016 583 1 View
I am working on a Parkinsons disease model in mice. The parkinsonian behaviour is scored before treatment starts. Each mouse has a specific score, which is based on the extend of the lesion (more...
04 April 2016 1,075 2 View
I want to look at how a specific disease affects the response of mouse smooth muscle towards a drug. I will need to construct a dose-response curve for my diseased sample vs control, however, I am...
05 February 2016 8,782 6 View
02 February 2016 5,138 7 View
Although human being do not clear the underlying mechanism of human common diseases such as cardiovascular disease, diabetes and osteoporosis, we try to model these disease based on the current...
12 December 2015 7,820 4 View
Are there methods available which discuss any possible combination of omics data e.g. Epigenomics, Transcriptomics, Proteomics, Metabolomics (any possible combination: Proteomic + Transcriptomic...
11 November 2015 2,187 1 View
Hi, Working on liver tumor, I'm looking for a CHC murin model on NASH background that could be set in short-term (about few months). I've seen that model could be chemically or diet induced, I...
11 November 2015 1,535 1 View
for bacterial infection i give 1* 10^9 cfu/ml (100ul) dose to mice,after 7 days mice are not infected.i need suggestion why mice r not infected. Because the article which i follow, in this with...
08 August 2015 6,235 2 View
One miRNA was found to increase in patients with a certain disease. In former experiments we found that intravenous injection of the human miRNA induced mouse injury like the human disease. We...
08 August 2015 6,085 9 View
MANY AUTHORS HAVE REPORTED DIFFERENT INCIDENCE AND TUMOR LATENCY FOR RAT MAMMARY TUMORS. CAN WE USE BOTH CARCINOGEN AT DIFFERENT TIME INTERVAL TO INDUCE TUMORS FAST WITH BETTER INCIDENCE?
06 June 2015 1,103 2 View