We induced Low grade chronic liver failure in rats by thioacetamide 50mg/kg OD intraperitoneally for 14 days (Singh 2014). We are also studying subsequent RENAL INJURY on this low dose . What disease model (DM/HTN/GN/NS) it closely resembles at this sub-acute low dose?. Most articles use a high dose (200-300mg/kg) to induce renal injury (oxidative stress).

Main HPE findings are:Decreased glomerular cellularity, Lobulation of glomerular tufts, widening of capsular space, dilatation of tubular lumina with desquamation of lining epithelium, disorganized tubular architecture, luminal dilation