Disease Models

Can we use combination of NMU and DMBA to induce mammary tumors in rats to get better incidence?

MANY AUTHORS HAVE REPORTED DIFFERENT INCIDENCE AND TUMOR LATENCY FOR RAT MAMMARY TUMORS. CAN WE USE BOTH CARCINOGEN AT DIFFERENT TIME INTERVAL TO INDUCE TUMORS FAST WITH BETTER INCIDENCE?

03 June 2015 8,092 2 View

What are the precautions to be taken and problems might be there to work with rabbit to create limbal stem cell deficiency model?

I would like to know the problems and knowledge with rabbit as an animal model for limbal stem cell deficiency (LSCD). I would appreciate if I got some link about the rabbit animal model, problems...

26 May 2015 4,227 1 View

What are the precautions to be taken and problems might be there to work with rabbit to create limbal stem cell deficiency model?

I would like to know the problems and knowledge with rabbit as an animal model for limbal stem cell deficiency (LSCD). I would appreciate if I got some link about the rabbit animal model, problems...

05 May 2015 1,967 1 View

Do zebrafishes get heart attack ?

i am curious about whether 'heart disease model zebrafishes' get heart attack or not?

01 January 2015 1,367 1 View

What's the difference between pretreatment of mice with streptomycin and sodium bicarbonate before oral infection of Salmonella typhimurium?

I want to develop a mouse Salmonella typhimurium oral infection model. The bacterium I used in this model was ATCC 14028.  I've read some articles, and the pretreatment was quite different, and I...

11 November 2014 2,188 6 View

Did anyone use the robust regression or Kalman filter for plant disease modelling?

I need the articles related to latest mathematical analysis such as robust regression or Kalman filter in developing the plant disease modelling especially related to perennial crop.

19 September 2014 8,212 1 View

How to develop Alzheimer's disease model in Zebrafish?

Can anyone suggest me how to initiate my work to develop Alzheimer's in Zebrafish?

10 September 2014 3,858 6 View

How to develop Alzheimer's disease model in Zebrafish?

Can anyone suggest me how to initiate my work to develop Alzheimer's in Zebrafish?

09 September 2014 1,014 7 View

How do you detect oligomeric bands of a protein by western blot?

Hi there, I've been trying to detect oligomeric bands of a protein (diseased mouse brain tissue) in western blot for some time. Immunostaining showed large aggregates of this protein in our...

09 September 2014 5,000 4 View

Did anyone use the robust regression or Kalman filter for plant disease modelling?

I need the articles related to latest mathematical analysis such as robust regression or Kalman filter in developing the plant disease modelling especially related to perennial crop.

09 September 2014 844 1 View

How does one develop better cell models to characterize common diseases and complex traits?

Whole genome sequencing and genome-wide association studies (GWAS) clearly demonstrate the complexity of common diseases and in the majority of cases risk cannot be defined by a single gene...

07 July 2014 5,860 2 View

Does anyone know of any mathematical models for chickenpox with vaccination?

A mathematical model for vaccination of chickenpox.

06 June 2014 5,728 4 View

Can anyone help me find a perfect model of Alzheimer disease?

I know there are transgenic animal models with on-off switching genes, but I am looking for a simple model which introduces complete Alzheimer symptoms without any gene manipulation. Is beta...

05 May 2014 8,816 15 View

How do you disrupt interaction among dendritic cells from T cells?

I am having problems in my sortings of CD8+ DC from spleens of chronically infected mice. I did a gene expression array and, after analysis, I identified a lot of T cell markers (CD3e, Thy1, CD8b,...

05 March 2014 4,064 5 View

How do you disrupt interaction among dendritic cells from T cells?

I am having problems in my sortings of CD8+ DC from spleens of chronically infected mice. I did a gene expression array and, after analysis, I identified a lot of T cell markers (CD3e, Thy1, CD8b,...

03 March 2014 7,476 6 View

Is there any advantage in including a Spatial Auto-Correlation term in a Geographically Weighted Regression model?

I have been using a spatial autocorrelation term in some Regression analysis modelling the rate of spread of disease. I am now attempting to model the same thing using Geographic Weighted...

11 November 2013 1,204 14 View

How far can one go in functional annotation of variants with the Zebrafish model?

I have seen a pretty interesting presentation by Dr. Nicholas Katsanis at the ESHG meeting who presented his work on functional annotation of variants found by exome sequencing. From what I knew...

06 June 2013 7,679 11 View

Where (at which lab/animal house) can i purchase C57BL/6 mouse strain; as i need it for my own research?

i need C57BL/6 mouse strain to induce an experimental disease model(EAE) for my own current research; as C57BL/6 mice strain are more susceptible to the disease induction than other resistant...

01 January 1970 9,139 3 View

In vitro models for studying viral hepatitis

My company is developing new tools for studying viral hepatitis, in particular HBV infection. I'm interested in finding out what hepatitis researchers are looking for in an in vitro model system....

01 January 1970 5,909 2 View

What model system do you use to study viral hepatitis?

Hi! I'd like to learn about the model systems you use to study viral hepatitis, in particular HBV. Your input will help my company to understand what hepatitis researchers like yourself need so...

01 January 1970 3,640 1 View

What is your over-arching goal for your project on Sphingolipid-based interaction between plants and herbivores?

Currently, I work in a lab that does research on Diabetes, Atherosclerosis, and Osteoporosis. I am the research specialist and am not involved in the hypothesis or theory of our project, I am just...

01 January 1970 7,445 2 View

Could anyone comment on adding evolution to disease modeling? Any good references?

For example, under what circumstances should we add evolution?  Does it have to be multi-scale problem? How to determine if evolution plays a big role in the disease models?

01 January 1970 9,689 4 View

In vitro models for studying viral hepatitis

My company is developing new tools for studying viral hepatitis, in particular HBV infection. I'm interested in finding out what hepatitis researchers are looking for in an in vitro model system....

01 January 1970 8,699 2 View

No title

01 January 1970 6,190 0 View