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Questions related to Animal Models
I want to keep Bax ( pro apoptotic member) continuously active in mouse model. Can any one suggests me a method of that? Thanks
06 May 2016 5,155 2 View
more specifically, I plan to use pigs as my animal models to test whether my materials containing rabbit TGF-beta, BMP2 can repair the cartilage defect. Since they are two different species, I am...
05 May 2016 5,017 1 View
I am interested in learning how to measure the alcohol levels in the animal model. Is there any assay or instrument that I can use? I am aware of ANALOX machine. However, it is tedious and the...
05 May 2016 2,100 3 View
I am desperately looking for second hand "2 cage units (tower) for rabbits", ca (1990-1995) , "LOCK SOLUTION" Medi Cage, Kenilworth New Jersey. They have a hinged lateral elevated platform, which...
05 May 2016 6,005 3 View
or any other animal model
05 May 2016 10,002 2 View
During controlled mechanical ventilation as compared to spontaneous breathing, less gradient of pressure in the system exists helping with repetitively opening and closing of the alveoli. When...
05 May 2016 6,975 9 View
We are just trying to figure out what our options are. Thank you!
05 May 2016 6,079 0 View
I know that mice are disqualified if they don't interact for at least 30 seconds during the test. I am wondering if there is literature on rats and what is considered too little interaction?
05 May 2016 8,545 4 View
I have a mutant zebrafish strain that likely has hypothryoidism as a result of the mutation. I am basing this on the fact that the adults are dwarfs compared to wild type fish and also do not...
05 May 2016 7,485 2 View
I want to inject mice with rolipram IP dissolved in about 5% DMSO once a day for 5 days. Is this dose of DMSO toxic?
05 May 2016 6,713 2 View
I need the best protocol to assay for serum high-sensitivity C-reactive protein (hs-CRP) levels in diabetic animal models?
05 May 2016 7,997 1 View
Can you suggest some established chemical inducers of epileptic seizures in rodents apart from PTZ alongwith dose and treatment period etc.?
05 May 2016 3,264 5 View
Hello, I would like to know if somebody has injected DAMGO (icv) in mice to evaluate food intake response. I have read a lot of papers where rats were animal model used, but I cannot find a...
05 May 2016 8,805 2 View
We use GFP as a fate map marker in chimeric mice. We are working on a protocol for a skin digest to analyze the turnover of leukocytes in the skin. The protocol works beautifully on a non-GFP...
05 May 2016 5,562 6 View
I've been using beta actin and also developed some tests with GAPDH in order to normalise my target proteins. However, since my animal model undergoes to hypoxia, as well as changes in muscle...
29 April 2016 4,530 6 View
I'm working with animal models for bipolar disorder to investigate lithium mechanisms of action. However i've been using lithium dosage based only in the suggestions from the literature. Indeed, I...
25 April 2016 2,734 3 View
I want to do the animal studies for the testing some compounds for anti-asthmatic activity. Please suggest me some models for the same.
15 April 2016 8,790 4 View
I will likely be using the hM4Di variant of DREADD and hope to avoid stressing the rat with an IP injection so close to a behavioral study that requires attention. IP will further be made more...
04 April 2016 326 3 View
04 April 2016 7,414 7 View
04 April 2016 8,576 4 View
Prostate cancer is the preferred indication to test Immune regulation, and androgen receptor activity. If not availabie, then another cancer type woudl be great to evaluate effects of the drug on...
04 April 2016 3,492 4 View
Does anyone know a simple protocol to fix in a 6-well plate and stain C. elegans with Oil Red O?
04 April 2016 6,323 0 View
04 April 2016 2,299 5 View
We administered Triton at a dose of 200mg/kg to experimental rats at a dose of 200mg/kg i.p. and after 10 minutes of injection the animals started showing writhing responses, suffocation and...
04 April 2016 9,977 5 View