I'm working with animal models for bipolar disorder to investigate lithium mechanisms of action. However i've been using lithium dosage based only in the suggestions from the literature. Indeed, I would like to check if the dosage i've been using is catching the right blood concentration that i'm expecting or not. How could I measure lithium levels in the blood?
Thanks!
Atomic absorption spectroscopy is a very easy/fast method for measuring serum Li+ levels.
http://www.scielo.br/pdf/jbpml/v50n1/1676-2444-jbpml-50-01-0012.pdf
Hello, Maria. I believe Chris is correct. Do you have access to that technology? You very well might in the Chemistry department or even in your own. If not, do you have access to clinical laboratory in medical pathology department or a veterinary lab? Either way, you are likely to find friendly colleagues who would treasure the chance to participate in your research. I agree with your thinking that lithium concentration will afford the most reliable way to compare results both for therapeutic effects and toxicity.
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