We administered Triton at a dose of 200mg/kg to experimental rats at a dose of 200mg/kg i.p. and after 10 minutes of injection the animals started showing writhing responses, suffocation and finally died.
Can anyone help me find out the reason for this and how to combat this problem?
Thank you.
Awoke Kassa Zewdie
due to high dose and this is bound to the trisodium of the dose.
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Beeravelli Sudhakar
Triton -x-100 is a surfactant and having high viscosity. generally it is usefull for lysis of molecules. it required dilution. when you injecting by i.p. animals are more suseptable to die due to high viscocity
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Sandhya Ch
Hello Grant Gallagher,
One of my co-researcher is using that method to induce hyperlipidemia in experimental rats. So....
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