Prostate cancer is the preferred indication to test Immune regulation, and androgen receptor activity. If not availabie, then another cancer type woudl be great to evaluate effects of the drug on effector cells.
Here are some common syngeneic cell lines that have been used in cancer immunotherapy mouse models:
1. For prostate, the TRAMP-C2 cell line in C57BL/6 mice. Forms subcutaneous and orthotopic tumors. This can also be engineered to express human PSA (there is no mouse PSA homolog).
2. For breast cancer, 4T1 in BALB/c mice. This model forms experimental metastases when injected IV or from subcutaneous tumors. Also can be used in an orthotopic model.
3. For melanoma, B16-F10 in C57LBL/6. Expresses many classical melanoma antigens such as Trp2. Forms tumors via many routes, including lung metastases following IV injection.
4. For colorectal cancer, CT26 in BALB/c mice. Another very good model that forms tumors following subQ, IP, IV and even intracranial injection. Also forms orthotopic tumors when injected into the intestinal wall.
All of these models work very well and my lab is experienced with cancer immunotherapy studies with each model if you want more details on any of them.
Hello Adam,
Would your lab be willing to run the Omnitura drug in the prostate model engineered to express PSA? There is interesting data published by Yuzhou Wang in Vancouver, BC.
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