Andrew Mtewa

34 Questions 259 Answers 0 Followers

Questions related from Andrew Mtewa

Please, any lab in Tanzania that is currently doing cytotoxicity tests on cancerous cell lines?

Please, any lab in Tanzania that is currently doing cytotoxicity tests on cancerous cell lines? Kindly let me know Regards

11 November 2018 3,110 0 View

How do I further isolate uncoloured fractions that show peaks on HPLC?

Hello Colleagues, I have several fractions (Hex:EtAc). In one small fraction (about 2mls), I got 6 peaks on HPLC. What do I need to do further or how do I need to separate these compounds,...

10 October 2018 1,652 8 View

How can I prepare a preparative TLC plate (PTLC) using silica gel? or where can I buy already prepared PTLC plates?

Dear Colleagues, Please help. How can I prepare a preparative TLC plate (PTLC) using silica gel? or where can I buy already prepared PTLC plates (Close to Malawi)?

09 September 2018 3,781 3 View

At what point does sequential solvent extraction make more sense? At crude extraction or fractionation?

Dear colleagues, At what point does sequential solvent extraction make more sense? At crude extraction or fractionation stage? One other thought would be to do crude extraction using MeOH and do...

08 August 2018 3,733 4 View

Which is better to extract: From fresh or dried plant samples?

which is better to extract from fresh or dried plant samples?

06 June 2018 660 0 View

What is you experience/knowledge about crossing borders with research plant sample extracts?

What is your experience/knowledge about crossing borders with research plant sample extracts? - Any challenges? - Noteworthy details? Please share Thank you and kind regards

06 June 2018 2,310 0 View

What are the most common non-material addiction drugs you know?

What are the most common non-material addiction drugs you know? - Please share if you know any conventional drugs on the market

06 June 2018 2,811 0 View

Is it worthy spending resources on researching orally and intravenously effective drugs from polar compounds?

Dear researchers, I understand that we can get drugs from polar compounds, but these are usually hardly bioavailable. This means the drug has to keep being modified to improve it's bioavailability...

06 June 2018 9,938 6 View

Do you know any medicinal properties of chlorophyll?

Do you know any medicinal properties of chlorophyll? Please share your ideas

06 June 2018 6,826 11 View

What is the best way of working with extremely busy co-authors in a manuscript?

Dear researchers, Sometimes we have to work with our highly respected co-authors that are extremely too busy to give time to our manuscriots, but for some important reasons, they have to be on the...

06 June 2018 10,040 22 View

Can drug synthesis be done based purely on molecular 'drug-like' properties? From proven bioactive extracts?

Can drug synthesis be done based purely on molecular 'drug-like' properties? From already proven bioactive extracts?

05 May 2018 3,313 2 View

Does anyone know if plant fossils (or their products) contain phytochemicals?

Does anyone know if plant fossils (or their products) contain phytochemicals? Are we looking at a newer source of drugs in fossils? Can this be possible or the compounds could long get...

05 May 2018 5,553 0 View

Please share any links or documents on specifications for drug tablets and syrup?

Please share any links or documents on specifications for drug tablets and syrup - Physical parameters as well as chemical parameters, I will appreciate

05 May 2018 6,615 0 View

How much do you share your failure stories with your students?

It is common knowledge for academicians and researchers to share success stories with their students to motivate them. However, failure stories may have a place in student motivation and...

05 May 2018 2,554 0 View

Collegues, what is the difference between an AChE inhibitor and a drug in molecular and mechanismistic terms?

Is an AChE inhibitor the drug molecule itself as a whole or it is contained in a drug molecule? Please assist

04 April 2018 8,465 7 View

Does any one have research articles on methods to do with Acylation and/or alkylation of anticancer drug molecules?

Please share if you have any on that area

04 April 2018 923 0 View

Are herbal medicines contributing to anti microbial drug resistance?

Microbials, kept subjected to several under-doses (mostly) and over-doses from herbal medicine use, are likely to develop resistance to particular drug molecules, which could also be the principle...

04 April 2018 4,319 6 View

How can I train a toddler to be excellent in numbers and science?

How can I train a todler to grow up, loving, liking and excelling in numbers and sciences? Please help with your knowledge from experiences or literacy

04 April 2018 9,602 0 View

How can communities help in ending hybrid warfare?

How can communities help in ending hybrid warfare? Can community 'ethics check' committees work? Do communities have this power at all?

04 April 2018 9,120 0 View

What is the best way to recruit your students into your research projects?

Hello Colleagues, Please let me know your opinions. How would/ do you recruit your students into your projects, both postgrads and undergrads? - Considering that they are usually busy (Mostly for...

04 April 2018 1,387 19 View

Is RG part of social media? is there anything like 'professional media'?

Social media sounds very unprofessional. What do we call RG and linkedin? professional media? Is this language true?

04 April 2018 9,113 6 View

How do you calculate a University workload for teaching staff, in your University?

Please help me know your ideas and understanding in your areas about how to calculate workload for a University teching staff, regardless of posts (Professors, etc). - It's easier to calculate...

04 April 2018 8,471 0 View

Can I undertake invitro and insitu permeability assays in any biochemistry lab or they require a specific class of a lab?

Colleagues, I need you help. Can I undertake invitro and insitu permeability assays in any biochemistry lab or they require a specific class of a lab?

04 April 2018 5,871 4 View

Does any one have articles on semi-synthesis protocols?

Please share if you have protocols on semi-synthesis or synthesis related to Q-structural activity relationships

04 April 2018 4,726 0 View

Is it ethical to administer a dose of a pharmaceutical product that is a week to its indicative expiry date?

Esteemed researchers and colleagues in the field, I visited a clinic years back where the pharmacist administered an eye ointment for my little todler son. The drug was four days towards expiry...

04 April 2018 3,680 9 View

How much is a 'justifiably' enough sample size?

Some say 30% of population for qualitative research Others say any sample size for quantitative research is good enough Please share your ideas on the question, both in qualitative and...

04 April 2018 5,156 5 View

Please help. How/where do people/researchers get national budgets for different countries, online?

I assume that national budgets are public information to citizens. It's easy for me to get one in my own country. But now for research purposes, how and where do people get national budgets for...

03 March 2018 3,228 3 View

How many and what stages should drug developers and discoverers plan for bioactivity tests of a drug material (Extract/fraction/molecule)?

During drug discovery and development, there is need for frequent tests of th drug material against particular biological targets. For project planning purposes, from plant to clinical trials, at...

03 March 2018 3,755 2 View

Can anticancer drugs be effective against wounds? and can anti-inflamatory drugs be effective against early stage cancers?

The relationship between cancers and inflamation is so great. Can these two, atleast at early stages, share drug?

03 March 2018 4,847 2 View

On "drug-like" properties in drug development, is the optimization of lipophilicity and PKa relevant for open wound drugs?

A proper drug molecule needs to be optimized to within some acceptable values for it to 'predictably' be considered an efficient drug or drug lead. This sounds logical for deep biological targets....

03 March 2018 7,459 4 View

Do I require ethical clearance to study drug action on insects?

I have a project on insectcides. Do I require specific ethical clearance as for animal models?

03 March 2018 3,176 0 View

In your own opinion, is africa progressing or stagnant in drug discovery and development? Please help?

Research in herbal medicine has been conducted vastly and still is in Africa. Africa has been able to develop herbal/complementary medicine of various kinds, present on the market. But has Africa...

03 March 2018 1,120 9 View

On the use of other solvents than water-Are our laboratory test results on ready-to-use herbal medicines (Beverages) limited, exergerated, irrelevant?

When patients take some herbal medicines, they usually use water as a solvent. Lab scientists test the same herb for efficacy and toxicity using Hexane, DCM, Et-Ac, MeOH/EtOH..., rarely do some...

03 March 2018 8,549 3 View

Can someone help me with the mechanism of anti dotes and a reason why some drugs have no anti dotes, please?

Drug use can potentijally have adverse toxic effects from for example over dose deliberately or otherwise. Other drugs are used to counter the toxic effects. However, there are some that do not or...

12 December 2017 2,784 2 View