Can drug synthesis be done based purely on molecular 'drug-like' properties?
From already proven bioactive extracts?
With the intention to improve the 'drug-like' properties by structural modification
If you have publications on this, please share
Please, any lab in Tanzania that is currently doing cytotoxicity tests on cancerous cell lines? Kindly let me know Regards
10 November 2018 3,023 0 View
Hello Colleagues, I have several fractions (Hex:EtAc). In one small fraction (about 2mls), I got 6 peaks on HPLC. What do I need to do further or how do I need to separate these compounds,...
09 October 2018 1,547 8 View
Dear Colleagues, Please help. How can I prepare a preparative TLC plate (PTLC) using silica gel? or where can I buy already prepared PTLC plates (Close to Malawi)?
08 September 2018 3,606 3 View
Dear colleagues, At what point does sequential solvent extraction make more sense? At crude extraction or fractionation stage? One other thought would be to do crude extraction using MeOH and do...
07 August 2018 3,616 4 View
Dear researchers, Sometimes we have to work with our highly respected co-authors that are extremely too busy to give time to our manuscriots, but for some important reasons, they have to be on the...
05 June 2018 9,949 22 View
What are the most common non-material addiction drugs you know? - Please share if you know any conventional drugs on the market
05 June 2018 2,728 0 View
What is your experience/knowledge about crossing borders with research plant sample extracts? - Any challenges? - Noteworthy details? Please share Thank you and kind regards
05 June 2018 2,226 0 View
which is better to extract from fresh or dried plant samples?
05 June 2018 529 0 View
Dear researchers, I understand that we can get drugs from polar compounds, but these are usually hardly bioavailable. This means the drug has to keep being modified to improve it's bioavailability...
05 June 2018 9,842 6 View
Do you know any medicinal properties of chlorophyll? Please share your ideas
05 June 2018 6,720 11 View
I have an input video, of skin (from a microscope that means it is magnified such that blood capillaries are visible). The idea is to extract 15 sec of continuous frames from a video of 1 min,...
02 March 2021 2,735 2 View
I am at the beginner level in drug design and drug discovery, and I am interested to learn more about this field. Which books are highly recommended to start from and gives me all essential...
02 March 2021 8,437 2 View
Hi all, I need to cleave the ester in Ethyl 2-amino-1H-imidazole-5-carboxylate to make the carboxylic acid and retrieve the product from solution to use in downstream applications of linking to...
01 March 2021 8,766 3 View
I need a procedure to extract the ciprofloxacin hydrochloride from aqueous solution by using dichloromethane in detail,. I thank you very much.
01 March 2021 4,306 1 View
I want to find a quorum sensing inhibitor from plant extracts. Klebsiella pneumoniae, Moraxella catarrhalis, Staphylococcus aureus, and Streptococcus pneumoniae. I looked for these strains...
01 March 2021 7,675 3 View
I am studying the potential of DCT and FFT coefficients extracted from a signal to classify the different objects that emit the signal. I applied the Shapiro-Wilk to confirm that data was not...
01 March 2021 8,079 2 View
The resultant solid was partitioned three times with 250 ml of petroleum ether (40-60/c) to remove any fatty material and evaporated to dryness.
28 February 2021 9,464 2 View
I have always been interested in geology and wondered about how unique structures of materials behave in different circumstances. I stumbled upon Olivine, the magnesium iron silicate, and heard...
28 February 2021 7,330 4 View
28 February 2021 8,466 2 View
Literatures on the piscicidal effect of sennaa alata is scanty. if you have any related litrature either in the bark, leaves or roots used as treatment to any aquatic organism please kindly help...
28 February 2021 9,138 2 View