Please share if you have protocols on semi-synthesis or synthesis related to Q-structural activity relationships
Please, any lab in Tanzania that is currently doing cytotoxicity tests on cancerous cell lines? Kindly let me know Regards
10 November 2018 3,023 0 View
Hello Colleagues, I have several fractions (Hex:EtAc). In one small fraction (about 2mls), I got 6 peaks on HPLC. What do I need to do further or how do I need to separate these compounds,...
09 October 2018 1,547 8 View
Dear Colleagues, Please help. How can I prepare a preparative TLC plate (PTLC) using silica gel? or where can I buy already prepared PTLC plates (Close to Malawi)?
08 September 2018 3,606 3 View
Dear colleagues, At what point does sequential solvent extraction make more sense? At crude extraction or fractionation stage? One other thought would be to do crude extraction using MeOH and do...
07 August 2018 3,616 4 View
Dear researchers, Sometimes we have to work with our highly respected co-authors that are extremely too busy to give time to our manuscriots, but for some important reasons, they have to be on the...
05 June 2018 9,949 22 View
What are the most common non-material addiction drugs you know? - Please share if you know any conventional drugs on the market
05 June 2018 2,728 0 View
What is your experience/knowledge about crossing borders with research plant sample extracts? - Any challenges? - Noteworthy details? Please share Thank you and kind regards
05 June 2018 2,226 0 View
which is better to extract from fresh or dried plant samples?
05 June 2018 529 0 View
Dear researchers, I understand that we can get drugs from polar compounds, but these are usually hardly bioavailable. This means the drug has to keep being modified to improve it's bioavailability...
05 June 2018 9,842 6 View
Do you know any medicinal properties of chlorophyll? Please share your ideas
05 June 2018 6,720 11 View
Hi all, I need to cleave the ester in Ethyl 2-amino-1H-imidazole-5-carboxylate to make the carboxylic acid and retrieve the product from solution to use in downstream applications of linking to...
01 March 2021 8,766 3 View
To do liquid biopsy and look for specific gene expressions there are so many published papers. Thera are different protocols and procedures used to isolate circulating cell free RNA or mRNA from...
23 February 2021 7,326 5 View
Hi everyone, I am a teacher of Heterocycles Synthesis, Is there a home practice that you recommend for undergraduate students? A simulator would also be useful Due to the pandemic, students...
18 February 2021 2,769 4 View
Can anyone recommend some any software/models available that can predict substance reactivities and the reaction yield under a specific set of reaction conditions process and proposing pathways to...
17 February 2021 2,383 3 View
I've been trying to quantitate mature microRNAs in 293T cells with and without 'X'. 2ug of total RNA (isolated by Trizol method) is converted to cDNA using All-in one microRNA cDNA synthesis kit...
17 February 2021 8,986 2 View
I am doing research on the synthesis of paracetamol. I am preparing acetic anhydride solution with a few drops a sulfuric acid and wish to measure the pH of this solution. However my pH meter...
14 February 2021 8,699 3 View
I have chemically synthesized silver nanoparticle to combat microbes on wound site. I have used many methods of synthesis, but I found minimal field of silver NP product.I am getting whitish...
11 February 2021 4,964 13 View
Hi everyone! I extracted RNA from urine pellet using phenol-chloroform method. The yield of RNA was 160ng/uL. 3uL of RNA was used for cDNA synthesis in 20 uL reaction using Go-Script kit....
05 February 2021 6,587 4 View
Hello, I am a synthetic polymer chemist. I would like to explore the simulation counterpart of my experimental work. Can anyone suggest a good software able to simulate polymerization reactions,...
04 February 2021 2,672 4 View
Dear colleagues I have the following questions concerning the safety of mRNA vaccines targeting the spike protein of SARS-Cov2: 1) The vaccine elicits antibodies which block the peptide domain...
04 February 2021 721 6 View