A proper drug molecule needs to be optimized to within some acceptable values for it to 'predictably' be considered an efficient drug or drug lead. This sounds logical for deep biological targets. Do drug like properties, in this case, PKa and lipophicity need to be optimized for drug molecules against topical biological targets, more so, open wounds?
Topical and systemic applications are very different. Of course, optimization of logP and pKa is very important for systemic drugs. However, the solubility and penetration of cell membranes could be also very important for topical drugs depending on their active concentration and mechanism of action (is the target outside or inside the cell), etc.
Thank you Prof. Petrikaite for your straight forward reply. It looks like optimization could still be a safe position of a discoverer as even solubility and permeability are affected by ionization and lipophilicity.
Thank you once again for your help.
Every drug candidate needs to be assessed and optimized for any rout of administration. A phisicochemical assessment is crucial for the developability of the target molecule.
Thank you Dr. Blasko, sounds like optimization is a 'must do' for an drug. Thank you once again.
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