Why there are two protein chains in Glucocorticoid receptor - DNA binding domain?

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Dominique Liger

Hi there,

DNA sequence recognized by GR is a palyndrome. One zinc finger of GR DBD is in charge to specifically bind one repeat motif. The second zinc finger acts in the dimerization of activated GR. The dimer formation allows the efficient binding to the 2 repeat motifs of GRE.

Kalani Jayanetti

Hi Dominique,

Thank you for your answer. Can you suggest me a reference if there any?

Hi again,

The following should help:

https://www.nature.com/nature/journal/v352/n6335/abs/352497a0.html