Why murin macrophages are in continuous division, whereas human are not?

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Amy Megan Smith

Interesting question, it seems that human macrophages don't always have the same (micro)environmental cues as murine macrophages.

A possible explanation is that more murine studies are performed with younger (neonatal) macrophages, compared to human adult macrophages.

Perhaps human macrophages have a higher threshold for inducing division (and activation) than murine macrophages.

Nadège Grabowski

Thanks a lot for your answer.