Why are mice exposed to radiation before inoculation of AML blast in xenograft engraftment?

03 March 2013 0 6K Report

I was reading a paper on Leukemia Stem cell and could not understand why mice were exposed to radiation before inoculation of CB lin- cells and surrogate neoplastic stem cells.

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Is there any qualitative or quantitative method to measure E3 ligase Ubiquitination invitro following drug treatment?

I would like to know if we can measure E3 ligase FBw7 activity or protein expression in breast cancer cells following drug treatment.

04 May 2013 2,269 2 View

Which cell lysis buffer recipe is best for phosphorylated proteins ?

I would be grateful to receive recipe for extracting total protein from breast cancer cell lines to see expression of phosphorylated proteins.

02 March 2013 1,465 12 View

What would be an easy experiment to check drug action on c-myc activity?

Specifically in breast cancer human (MCF-7 , MDA MB 231) and mouse mammary epithelial cells.

01 February 2013 803 3 View

Which is the best software to design cDNA primers and where is it available?

Tutorials for designing primers and trouble shooters are equally appreciated.

01 February 2013 2,268 4 View

What are the emerging trends and opportunities for STEM education and careers in the online space?

10 August 2024 507 0 View

Which Scopus Journal provides the most affordable fees?

"PUBLISHING IN A SCOPUS JOURNAL" Researchers are now at a cross road. The critical need to publish in a Scopus or ISI, etc journal is ever vital. Journal Publication fees must be submitted....

10 August 2024 8,621 1 View

Seeking Advice on Viability and Execution of Undergraduate Thesis Topic?

Hello everyone, I am currently developing a thesis proposal and would appreciate your input on its viability and how to effectively carry it out. My proposed topic is: "Does the perceived threat...

10 August 2024 8,992 0 View

Who will be moral responsible for the death of thousands of people in the event of an earthquake?

Who will bear moral responsibility for the deaths of thousands of people in the event of an earthquake? Weeks and months remain before the onset of strong earthquakes that bring death to...

08 August 2024 6,134 12 View

Is there any way to quantify bacterial and fungal cells in their mixed culture?

I am working in fungal fermentation of soybean meal and there is bacterial growth in them at times. I am trying to quantify fungal cell counts and bacterial cells; but I haven't been able to do at...

07 August 2024 7,535 4 View

Why activated CAR-Jurkat cell could not kill targets?

Previously when I co-coluture anti-CD19(FMC63) CAR-Jurkat with Raji with E:T=5:1, Jurkat can eliminate Raji in 24h. However, when I test another CAR construct, although I can dectect totally CD69...

06 August 2024 641 2 View

Are there any instruments for studying time similar to the way it is in space?

There are a huge number of methods for studying objects in space, according to the senses (and not only). Mechanical, thermal, optical, acoustic, electrical, magnetic, based on particle beams,...

06 August 2024 7,102 0 View

Research Methodology - Impact of Corporate Reputation on Stakeholders Behaviors?

Please can anyone support with the survey questions based on RQ measures and propose how to do it in FMCG industry and include as well the role of brand equity Thanks

06 August 2024 949 0 View

How much total RNA concentration to be extracted from sorted plasma cells from bone marrow of C57BL/6 mice for RT-PCR ?

i have sorted anti-NP specific plasma cells from bone marrow of C57BL/6 mice at certain times after immunization with variable counts and isolated total RNA using TRIZOL method for RT-PCR using...

05 August 2024 8,835 1 View

Anyone having idea about VN primer for miRNA primer design ?

How to design VN primer to attach with universal reverse primer

05 August 2024 2,116 3 View