In order to screen the hypolipidemic drugs, Triton induced hyperlipidemic animal model is being used. In most of the papers, Triton WR 1339 (tyloxapal) was used to induce hyperlipidemia. However, in some paper Triton X 100 was used. Which Triton is best or ideal to induce hyperlipidemia in rat model.
Thanks in advance for replies.
I have used Triton WR-1339 (Tyloxapol) to induce a transient hypertriglyceridemia by blocking the lipase activity (that hydrolyzes TG-rich Lp), in order to assess liver VLDL-TG production in mouse models.
Triton WR-1339 (Tyloxapol) is beneficial to induce hyperlipidemia.
Triton WR-1339 reliably induces hyperlipidemia in rodents treated with it without fatalities unlike triton X-100 which kills animals as a result of its attendant hemolysis for which it is notoriously reputable.
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