We need to test our herbal drug with diet induced hyperlipidemic animal model (Sprague Dawley rats) and we have gone through literature to know about high fat diet. There are many protocols to induce hyperlipidemic state, which involves cholesterol, cholic acid, and coconut oil, or lard. However, when we drying, the rats are not eating the food, that was made from coconut or lard?.
If any one experience with successful protocol to induce hyperlipidemia, please share with us.
Thanking you in advance for your replies.
Just try Triton induced hyperlipidemia if oral feeding is difficult.
Check the link..
http://link.springer.com/article/10.1007%2FBF02531272
All the best
Hello Sir, and Madam,
I am aware about the chemically induced hyperlipidemia by Triton WR 1339. However, my experimental design demands diet induced hyperlipidemic model. While administering the cholesterol and cholic acid with food, i encounter the problem that, rats dont take the food as usual due to the coconut oil, or lard. First, i want to confirm that, others also have the same experience or not?. Now, i do understand that, i can administer the cholesterol and cholic acid by oral intubation.
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