Hi dears
I am transferring in-vitro activated CD8+ T cells into host mice IV.
They can enter the liver and accumulate around the infected hepatocytes expressing the antigen.
I am wondering which chemokines and chemokine receptors are involving in the homing of these cells in the liver and their accumulation around infected hepatocytes.
please if you have any suggestion let me know.
Kind regards
Dear Masoud,
we have tested CXCL10 KO and CCL5 KO mice in our mouse model for autoimmune hepatitis (Holdener et al (2008) J Exp Med) and found opposite effects. Whereas the liver damage and infiltration was reduced in CXCL10 mice its was enhanced in CCL5 KO. Therefore I would check for CXCL10 expression in your model. We are currently preparing a manuscript about our data, so I guess they will be available next year.
All the best
Urs
Dear Masoud,
we have tested CXCL10 KO and CCL5 KO mice in our mouse model for autoimmune hepatitis (Holdener et al (2008) J Exp Med) and found opposite effects. Whereas the liver damage and infiltration was reduced in CXCL10 mice its was enhanced in CCL5 KO. Therefore I would check for CXCL10 expression in your model. We are currently preparing a manuscript about our data, so I guess they will be available next year.
All the best
Urs
Thank you dear Urs
Your answer is amazing. I am reading your paper (Breaking tolerance to the natural human liver autoantigen cytochrome P450 2D6 by virus infection).
I am looking forward reading your next paper.
Wish you all the best
Masoud
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