Hi, anyone knows which animals are suited for a aortic formation study (cardiovascular disease) - rat or rabbits? Rat has a tiny aorta which is difficult to be sampled and cut compared to rabbit.
I agree with Faria-Neto.
Rats are not a good model for atherosclerosis. You will hardly verify formation of atheroma. The ideal is to use mice, especially genetic modified mice, which are the best option.
Rats are not a good model for experimental atherosclerosis. If you want to work with rodents, genetic modified mice are a better option (either ApoE Knockout or LDLr knockout). If this is not an option, rabbits are fine.
I agree with Faria-Neto.
Rats are not a good model for atherosclerosis. You will hardly verify formation of atheroma. The ideal is to use mice, especially genetic modified mice, which are the best option.
dear colleague : rat ou rabbit? depend what you intend to study. please be more specific
best regards
Knockout studies are not possible with rats. my bet is on mice and specially for atherosclerosis, use ApoE ko mice fed with high cholesterol diet.
My supervisor said mice or rat has tiny or small size of aorta to be sample. Tendency to miscut the aorta is high. Anyone can discuss about this?
Aneurysms are common in the abdominal and thoracic regions of the aorta. While generally asymptomatic, progression of aneurysms is associated with the devastating consequences of aortic rupture.
www.ncbi.nlm.nih.gov/pubmed/25060754
The pathogenesis of abdominal aortic aneurysm (AAA) formation is complex and not fully understood. Certain epidemiologic risk factors are associated with AAA development, such as male sex, cigarette smoking, hypertension, advanced age, atherosclerosis, and a genetic predisposition. However, the relationship between these risk factors and the biological process of aneurysm formation is not clear.
http://www.vascularweb.org/research/Pages/the-pathogenesis-of-abdominal-aortic-aneurysms.aspx
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