What's the difference between fibrosis caused by M1 and M2 macrophage respectively?

26 October 2022 0 2K Report

Hi!

It is known that in wound healing and foreign body reaction, M1 macrophage is responsible for recruiting fibroblast and cause fibrosis. However, studies have also shown that forcibly polarize macrophage into M2 also cause more fibrosis with excessive secretion of TGF-B. What's the difference between fibrosis caused by M1 and M2 macrophage respectively?

Also, some previous study of bioglass and zwitterionic hydrogel give nearly 0 thickness of Foreign body reaction thickness. To present such minimize fibrosis, how is the M1-M2 balance altered behind?

Thanks!

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