The abstract is as follows:

Title: Quality of life of Iranian adults with neurofibromatosis 1: validity and reliability study

Abstract

Aim: Evaluate the quality of life of Iranian patients with neurofibromatosis and the validity and reliability of the Persian version of the NF1 adult HRQOL questionnaire (NF1-AdQOL).

Methods: This methodological study was conducted on 414 adults’ patients with neurofibromatosis 1 in Iran, using convenience sampling. Based on permission from the developer of the scale, it was back‐translated. Content validity, exploratory and confirmatory factor analyses were tested. The reliability of the questionnaire was evaluated with test-retest and internal consistency.

Results: The 31-item Quality of Life questionnaire was translated into Persian, and based on content validity two of the items were removed. The adequacy of the sample was acceptable (KMO = 0.940). Exploratory factor analysis revealed four factors. The scale was good reliability (Cronbach’s alpha: 0.953), and the intraclass coefficient was 0.91. The total mean Quality-of-life score was 93±25.18.

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