You are right. there are some conflicting reports about the solubility of levofloxacin hemihydrate in water. Some sources indicate that it is insoluble in water, others state that is sparingly soluble in water.
The truth is:
The molecule exists as a zwitterion at the pH conditions in the small intestine.
The data demonstrate that from pH 0.6 to 5.8, the solubility of levofloxacin is essentially constant (approximately 100 mg/mL). Levofloxacin is consideredsoluble to freely soluble in this pH range, as defined by USP nomenclature. Above pH 5.8, the solubility increases rapidly to its maximum at pH 6.7 (272 mg/mL) and is considered freely soluble in this range. Above pH 6.7, the solubility decreases and reaches a minimum value (about 50 mg/mL) at a pH of approximately 6.9.
WHO. Working document QAS/10.360/Rev.1 September 2010
Levofloxacin Solubility. Slightly soluble in water, soluble in glacial acetic acid, slightly soluble or soluble in dichloromethane, slightly soluble in methanol.