Hi Aparna Liza

A strategic approach to finding new uses for existing medications.

• Disease-Centric: This method focuses on identifying existing drugs that might be effective for a new disease. Researchers look for connections between the new disease and diseases the drug already treats, or similar biological pathways involved.
• Target-Centric: This approach concentrates on a specific molecular target known to be involved in a new disease. Researchers then examine approved drugs that interact with this target, exploring their potential for treating the new disease.
• Drug-Centric: This method flips the script - instead of a specific disease, researchers investigate a drug with a known mechanism of action. They then explore if this mechanism could be beneficial for other diseases with similar underlying biology.

In simpler terms, identify the disease of interest, select the pathway that is recently being explored in the disease and the identify a drug that has been explored in similar pathway for another disease treatment or inhibits any specific protein from the same pathway.

Hope it helps,

Thanks,

1. It is important to know the mechanism of the drug intracellular action. 2. The drug can be targeted to the definite cell population with the additional tools. 3. It is better to target the regulatory cells than executive ones.