Talking with colleagues, it seems that the possible usefulness of an HPLC method development software repeatedly comes into the analyst's mind during the development of a tough HPLC/UPLC assay. Could you share your experiences with HPLC method development software? Which one would you choose and why (reliability, ease of use, intuitive usage etc)? With real samples, do they provide information as reliable as stated by the vendors? Are there any drawbacks?