I tested the toxicity of a drug in mice. I found increased collagen in the spleen. Can someone please share some paper to find out the reasons of this increased collagen deposition in the spleen. Thanks.
Louis Stéphane IV Le Clercq
Hi Abdullah Abdullah ,
My best guess would be fibrosis as a sign of splenic toxicity. Fibrosis is defined as "the development of fibrous connective tissue as a reparative response to injury or damage". This has come up in other toxicity studies in rodents and is similar to hepatotoxicity.
See: Article Oxidative Stress in the Splenotoxicity of Aniline
orArticle Chlorpropham-induced splenotoxicity and its recovery in rats
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