If I understand the Lambda genome correctly it seems that some of the sequence of genes isn't the most logical. When the phage enters the lytic cycle its late rightward promoter first transcribes the genes that actually achieve host lysis including the lysin, spanin, and holins (genes R, S, RZ) and only then continue through to the structural and DNA packaging genes (genes nu1 to J). Wouldn't it seem more logical for the phage particles to begin being produced before cell lysis is initiated allowing a bit of a head start to release the most phage as possible? Is it that the difference in expression time between the gene products is really inconsequential, or does the actual lysis require a buildup of the lysins, etc that allows sufficient time for phage production? What would be the effect of engineering the phage to reverse the order of the genes?

Also regarding the capsid proteins, it is known that the stabilizing decoration protein gpD only attaches to the capsid after it is formed. Yet it would appear from the sequence of the genes that gpD is actually expressed before the major capsid protein gpE. Again is the order of gene expression just not as significant as I would have thought or is there a reason for the way the genome is arranged?

Thanks in advance for helping with what might be a silly question.

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