I can provide a brief simplified explanation:
Downregulation by a cell is the process of decreasing the quantity of a cellular component, which may be a protein or a receptor or RNA, for instance, in response to an external signal, while upregulation is the process of increasing a cellular component. The downregulation of a surface receptor for example decreases the number of molecule receptors, and the effect of this is the reduction of the cell's sensitivity to that molecule.
MicroRNA downregulation is the reduction in the quantity of small non-coding double-stranded RNA molecules called MicroRNAs that are critical in the regulation of gene expression. MicroRNAs in cancer can play the opposite roles of either tumor suppressors or oncogenes. So for example MicroRNA-148b is often down-regulated in gastric cancer, and it happens to act in this context as a (good) tumor suppressor, inducing inhibition of cell proliferation (Song et al., Mol Cancer. 2011). But on the other hand MicroRNA-31 functions as an oncogenic microRNA in lung cancer cells (Liu et al., J Clin Invest. 2010). Whether we obtain, therefore a positive tumor suppressor (anticancer) effect or a negative oncogene (pro-cancer) effect depends on the specific MicroRNA, on whether it is up- or down-regulated, and on the specific context (the specific cancer under study for instance.
Constantine Kaniklidis
Director of Medical Research,
No Surrender Breast Cancer Foundation (NSBCF)
European Association for Cancer Research (EACR)
Maulik I do not know answer to this question as it does not nelong to my field. I invite you to vidit www.mdegq.com and join us.
I can provide a brief simplified explanation:
Downregulation by a cell is the process of decreasing the quantity of a cellular component, which may be a protein or a receptor or RNA, for instance, in response to an external signal, while upregulation is the process of increasing a cellular component. The downregulation of a surface receptor for example decreases the number of molecule receptors, and the effect of this is the reduction of the cell's sensitivity to that molecule.
MicroRNA downregulation is the reduction in the quantity of small non-coding double-stranded RNA molecules called MicroRNAs that are critical in the regulation of gene expression. MicroRNAs in cancer can play the opposite roles of either tumor suppressors or oncogenes. So for example MicroRNA-148b is often down-regulated in gastric cancer, and it happens to act in this context as a (good) tumor suppressor, inducing inhibition of cell proliferation (Song et al., Mol Cancer. 2011). But on the other hand MicroRNA-31 functions as an oncogenic microRNA in lung cancer cells (Liu et al., J Clin Invest. 2010). Whether we obtain, therefore a positive tumor suppressor (anticancer) effect or a negative oncogene (pro-cancer) effect depends on the specific MicroRNA, on whether it is up- or down-regulated, and on the specific context (the specific cancer under study for instance.
Constantine Kaniklidis
Director of Medical Research,
No Surrender Breast Cancer Foundation (NSBCF)
European Association for Cancer Research (EACR)
Thank you for good explanation of my question. I think it will help me a lot for understanding my research more perfectly.
Maulik:
Glad to help - besides being a researcher, I also am an educator in these arenas, so if I can help in anything further just let me know.
Dear Constantine Kaniklidis,
Thank you for your great help. I am pursuing my PhD on MicroRNA in Human cancer from Veer Narmad South Gujarat University, Gujarat, India. Due to less research availability here i am facing much problem for guidance for this particular subject. If you said for help, i would like to discusses my project with you for guidance.
Maulik:
Yes, that would be fine - I know resources can be very constrained - and I will provide whatever guidance I can that you request. You can either post here (on ResearchGate), which would allow others to possibly participate, but should you prefer to contact me privately by email, let me know and I will give you my email address in a private message.
Dear Constantine Kaniklidis, thank you for you help. if you can provide your email, i will send a mail direct to you, it i think better way to discuss. i would try to participate in EMBO Conference held on heidelberg germany during Oct-2013 "The Non Coding Genome", for that i planning to represent my work. so i need your valuable suggestion and guidence.
Thank you.
Maulik:
Sure. you can reach me at my private email address:
Kind regards
Constantine
To,
Constantine Kaniklidis
Sir I was mailed you on your email ID. Please go through it and guide me for my Project.
Maulik
- Badges
- Science topic
- Similar topics
- Biological Science
- Biochemistry
- Biomolecules
- Nucleic Acids
- RNA
- Small RNA
- microRNA