Hello,
I have to prepare polyphenolics loaded chitosan nanoparticle. so, what mw of chitosan should i select to get the less particle size with good zeta value and consistent drug release.
About 100kDa -but degree of deacetylation is also very important
Franca, E.F., Freitas, L.C.G. & Lins, R.D., 2011. Chitosan molecular structure as a function of N-acetylation. Biopolymers.
Hi,
The following literature may have answers to your question:
Polyphenol-chitosan conjugates: Synthesis, characterization, and ...
https://www.ncbi.nlm.nih.gov/pubmed/27474608
by Q Hu - 2016
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Study of the interactions between polyphenolic compounds and chitosan
www.sciencedirect.com/science/article/pii/S1381514800000092
by MI Popa - 2000
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Chitosan crosslinked microparticles with encapsulated polyphenols ...
jba.sagepub.com/content/30/5/618.short
by K Trifković - 2015
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