see this interesting review:
Critical Reviews in Oncology/Hematology
Volume 85, Issue 2, February 2013, Pages 95–111
Issues to be considered when studying cancer in vitro
Beata Čunderlíková, ,
International Laser Centre, Ilkovičova 3, 841 04 Bratislava, Slovakia
Abstract
Various cancer treatment approaches have shown promising results when tested preclinically. The results of clinical trials, however, are often disappointing. While searching for the reasons responsible for their failures, the relevance of experimental and preclinical models has to be taken into account. Possible factors that should be considered, including cell modifications during in vitro cultivation, lack of both the relevant interactions and the structural context in vitro have been summarized in the present review.
salam
Passage Number Effects In Cell Lines
http://www.atcc.org/Portals/1/Pdf/tb07.pdf
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