Hello,
I’m studying the role of EHD2 in regulating caveolae dynamics, particularly its function in stabilizing caveolae at the plasma membrane. I’m interested in knowing:
- What are the known inhibitors or molecules that specifically prevent EHD2 from entering the nucleus?
- Are there compounds or interventions that can disrupt EHD2’s function in inhibiting caveolae internalization on the cell surface?
Thanks in advance for any insights!
Hello, Fan Janice .
We have not found any inhibitors targeting the nuclear import of EHD2, because in general, EHD2 exists in the cytoplasm, and its nuclear import process is not a research hotspot, so the development of targeted inhibitors is relatively small.
The proteins involved in the endocytosis of cell membrane caveolae include the caveolin family, EHD2, Dynamin, etc.
We recommend the Dynamin inhibitor Dynamin IN-2 (HY-152216, MCE). This is an analog of Wiskostatin (HY-12534) that can effectively inhibit the action of Dynamin, with an IC50 of 1.0 μM for Dynamin I GTPase. Dynamin IN-2 can also block clathrin-mediated endocytosis (CME), with an IC50 of 9.5 μM.
Or we recommend Dynasore (HY-15304, MCE), which is a commonly used inhibitor targeting Dynamin that can inhibit the process of caveolae endocytosis. However, it should be noted that Dynasore is not a specific inhibitor of Dynamin and may interfere with other related processes.
The answer to this question comes from MedChemExpress (MCE) Technical Support.
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