Hi Mohamed
Both of H1299 and A549 lung cancer cell lines are used for scientfic research. you can search google for them you will fined many papers like the following.
The repair capacity of lung cancer cell lines A549 and H1299 depends on HMGB1 expression level and the p53 status
Shazie Yusein-Myashkova, Ivan Stoykov, Anastas Gospodinov, Iva Ugrinova, Evdokia Pasheva
The Journal of Biochemistry, Volume 160, Issue 1, July 2016, Pages 37–47, https://doi.org/10.1093/jb/mvw012
Published:
19 February 2016
Metabolic cooperation between co-cultured lung cancer
cells and lung fibroblasts
Michael I Koukourakis1
, Dimitra Kalamida1
, Achilleas G Mitrakas1
, Maria Liousia2
, Stamatia Pouliliou1
, Efthimios Sivridis2
and Alexandra Giatromanola
Radiosensitization of p53-Deficient Lung Cancer Cells by Pre-treatment with Cytostatic Compounds
SERGEY V. TOKALOV1,3⇓ and NASREDDIN ABOLMAALI1,2
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Author Affiliations
1Biological and Molecular Imaging, OncoRay - National Center for Radiation Research in Oncology, Carl Gustav Carus Medical Faculty, Dresden University of Technology, Dresden, Germany
2Institute and Polyclinic for Diagnostic Radiology, Carl Gustav Carus Medical Faculty, Dresden University of Technology, Dresden, Germany
3Development and Regeneration Department, Foundation Caubet-CIMERA, Bunyola, Balearic Islands, Spain
Correspondence to: Dr. Sergey Tokalov, Development and Regeneration Department, Foundation Caubet-CIMERA, Ctra. de Soller km 12, 071100 Bunyola, Ballearic Islands, Spain. Tel: +34 971011783, Fax: +34 971011798, e-mail: [email protected]
a549 cell line has a Kras mutation.
h1299 has a p53 deletion mutation. The absence of p53 expression at a decent level renders this cell line immortalized.
hope it helps.
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