I found vWF, PAI1 and FVIII that are produced by endothelial cells, but I think there must be more, maybe more important factors to mediate coagulation process.
I recommend that you read the attached paper that describes the “mammalian stress mechanism” that was anticipated by Dr. Hans Selye. Better yet, read my book called “Fifty Years Lost in Medical Advance: The Discovery of Hans Selye’s Stress Mechanism” that is available from Amazon.com.
The vascular endothelium is the focus of stress mechanism activity. It manufactures von Willebrand Factor (VWF) and releases it into blood circulation in accord with sympathetic nervous activity. VWF binds to hepatic enzymatic factor VIIIC to form a gigantic molecular complex called “factor VIII.” This stabilizes VIIIC and enables its enzymatic activities that produce a protein polymer called “insoluble fibrin” that regulates blood coagulability and microvascular flow resistance.
The vascular endothelium also isolates tissue factor in extravascular tissues from blood enzymes. Damage to the vascular endothelium exposes tissue factor (TF) to hepatic enzymatic factor VII. TF binds to factor VII to enable its enzymatic activities which enable tissue repair.
Try reading my paper, which will provide far more detail. Better yet, read my book.
To answer your question directly, the vascular endothelium produces multiple substances that either promote or inhibit coagulation. These include all of the following, and no doubt others presently undiscovered:
TFPI (tissue factor pathway inhibitor)
ATIII (antithrombin)
Protein C
PAI (plasminogen activator inhibitor)
TPA (tissue plasminogen activator)
NO (nitric oxide)
Fibronectin
Vitronectin
glycocalyx
Most of these substances remain poorly understood at this time. It is my hope that the presently crude description of the mammalian stress mechanism will provide a fresh “prevailing paradigm” of medical research that will clarify their operation and inspire effective new medications that cure amyloidosis, and eliminate chronic illness. Try the electronic version of my book, because it includes electronic links to the references that will help you understand what is presently known about these agents. Check the attached diagram.
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