The mechanism of the new method Cancer Therapy exhibits combination Prolonged medical starvation 42 - 45 days with considerably decreased dosage of cytotoxic drugs which was described in detail in the article: Ponizovskiy M.R., The detailed description mechanisms of the herbs extracts operations in the new method cancer disease treatment via rearrangement of metabolism from pathologic development into normal development, Journal of Clinical Trials, 2012, v. 2, Issue 4, doi:10.4172/2167-0870.1000124. The mechanism of this method of cancer therapy operates via Warburg effect targeting. The purpose of this work is substantiation the supplementary mechanisms of efficient Cancer Therapy via combination “Prolonged medical starvation” with considerably decreased dosage of cytotoxic drugs and also substantiation advantage of this method of cancer therapy in comparison with cancer treatment with great dosage of cytotoxic drugs. There were described the biochemical and biophysical mechanisms of formations resistance to some cytotoxic drugs and recurrence cancer disease after modern methods chemotherapy with large dosage cytotoxic drugs after some disease remission. Also it was described the benefits of use the method “Prolonged medical starvation” with decreased dosage of cytotoxic drugs for cancer treatment. It was substantiated the mechanism operation of this method cancer treatment, which leads to suppression cancer metabolism of Warburg Effect and create depression of cancer disease metabolism without resistance to decreased dosage of anticancer cytotoxic drugs in comparison with intensive anticancer chemotherapy with great dosages of cytotoxic drugs which violate immune and hormonal defensive systems of an organism. The offered method Cancer Therapy should be made by Clinical Trial for introduced into official practical medicine.
Dear Dr. P.F.Zabrodskii, I am glad to communicate with you on topic of new method of cancer treatment which were published in many my articles as well as in the my book entitled "Biophysical and Biochemical Mechanisms of Organism Development in Norm and Pathology" [Please, familiarize yourself with the book entitled „Biophysical and Biochemical mechanisms of organism development in norm and pathology“. This book is published by Publishing House of "Cambridge Scholars Publishing" and is intended for the specialists and the scientists in fields of medicine and biology. This book advances the knowledge of the mechanism development of a lived organism during its lifetime through the normal stationary state and quasi-stationary pathologic state from the viewpoints of biochemistry, biophysics, and thermodynamics. It explores the possibility of estimating experimental results from the point of view giving a broad perspective on the interaction between an organism and its enviroment. The book also describes the biophysical and biochemical mechanisms maintenance stability of internal energy according to the First and Second laws of Thermodynamics in norm and pathology. There were described in the Chapters 4, 5, 6 of the book mechanisms of oncogenesis, relapse cancer, resistance to cytotoxic drugs by cancer diseases as well as described the offered of the new efficient method cancer treatment creating comparison with modern methods of chemotherapy with large dosage of cytotoxic drugs. Also the book describes the role of Stem cells in regenerative medicine. Besides the book gives the scientific proof of the immortality of a human soul after death.
Also attached in email the announcement of book can be viewed with commentaries via website: https://www.cambridgescholars.com/product/978-1-5275-0711-1 ].
Apropos, House Publication "Cambridge Scholars Publishing" will soon publish one more Book in paperback which will be sold for £39.99, versus the above presented book in hardback be sold for £78.99. Also I hope that our community will be able to achieve Clinical Trial of the new efficient method of cancer treatment to introduce this efficient method of cancer treatment in official medical practice.
I look forward your response.
Dr. M.Ponizovskiy
Dear Dr. P.F.Zabrodskii, I am glad to communicate with you on topic of new method of cancer treatment which were published in many my articles as well as in the my book entitled "Biophysical and Biochemical Mechanisms of Organism Development in Norm and Pathology" [Please, familiarize yourself with the book entitled „Biophysical and Biochemical mechanisms of organism development in norm and pathology“. This book is published by Publishing House of "Cambridge Scholars Publishing" and is intended for the specialists and the scientists in fields of medicine and biology. This book advances the knowledge of the mechanism development of a lived organism during its lifetime through the normal stationary state and quasi-stationary pathologic state from the viewpoints of biochemistry, biophysics, and thermodynamics. It explores the possibility of estimating experimental results from the point of view giving a broad perspective on the interaction between an organism and its enviroment. The book also describes the biophysical and biochemical mechanisms maintenance stability of internal energy according to the First and Second laws of Thermodynamics in norm and pathology. There were described in the Chapters 4, 5, 6 of the book mechanisms of oncogenesis, relapse cancer, resistance to cytotoxic drugs by cancer diseases as well as described the offered of the new efficient method cancer treatment creating comparison with modern methods of chemotherapy with large dosage of cytotoxic drugs. Also the book describes the role of Stem cells in regenerative medicine. Besides the book gives the scientific proof of the immortality of a human soul after death.
Also attached in email the announcement of book can be viewed with commentaries via website: https://www.cambridgescholars.com/product/978-1-5275-0711-1 ].
Apropos, House Publication "Cambridge Scholars Publishing" will soon publish one more Book in paperback which will be sold for £39.99, versus the above presented book in hardback be sold for £78.99. Also I hope that our community will be able to achieve Clinical Trial of the new efficient method of cancer treatment to introduce this efficient method of cancer treatment in official medical practice.
I look forward your response.
Dr. M.Ponizovskiy
Firstly, the proposed experimental works of oncogenesis are also described in my published works, e.g. one of these works: Ponisovskiy M.R., (2010), “Cancer metabolism and the Warburg effect as anabolic process outcomes of oncogene operation”, Critical Reviews in Eukaryotic Gene Expression, 20 (4), 325 – 339. But experimental works of oncogenesis are not touched on the methods of Cancer Therapy.
Secondly, the viral etiology of cancer disease is not rejected ever today and ever will be remained through 100 years.
Thirdly, all current methods of cancer treatment are used the large doses of cytotoxic drugs which suppress of the organism's defense mechanisms of immune systems and hormonal systems versus to new method of cancer treatment which minimal doses of cytotoxic substances are the advantage of new method cancer therapy. Please, don't forget this!
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