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Suppose you have T cell "A" that gets activated by cognate antigen and differentiates into an effector cell.
Part of the differentiation is epigenetic programming into an effector cell fate. Activation results in its engaging the cell cycle and proliferating into Cells "B" and "C" Do cells "B" and "C" inherit the effector epigenome? Or do they start as naive T cells until they see antigen?
In other words, suppose that only cell "A" sees antigen and becomes an effector, do cells "B" and "C" become effectors by default? Thank you...
Gregory Dressler
I am not an immunologist, but I believe they would inherit the effector phenotype if differentiation is truly an epigenetic phenomenon.
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