What are the microRNA-drug interaction databases?

I am looking for databases that contain microRNA-drug interactions. Any suggestions or recommendations?

09 October 2019 5,273 4 View

MicroRNAs in Breast cancer?

I need to get the list of microRNAs involving in breast cancer. is there any review paper, database, online tool, etc.?

06 July 2018 4,698 0 View

How to calculate drugs/compounds similarity?

I need to construct n*n similarity matrix of n drugs/compounds. I need an online or offline tool to construct this matrix. I have the SMILE of drugs/compounds. any suggestion or recommendation?

11 December 2017 701 2 View

How can get 3D structure of my desire protein sequence in PDB format??

I need PDB format of my desire proteins. I have their sequence. how can I get me question solved?

02 March 2016 2,152 1 View

Where & How can I get full 3'-UTR sequences for Bos taurus?

I need full 3'-UTRs for Bos taurus. who knows where I can get this fasta file? please share any link if is possible.

10 November 2014 5,140 0 View

Where can I get validated negative interaction?

I'm in need of experimentally validated microRNA negative interaction. I got validated positive interactions from mirtarbase. But I don't know where to get negative ones. Please share if you have...

03 April 2014 662 1 View

What is the difference between microRNAs with star and without star?

For example what's the difference between these 4 microRNAs? hsa-miR-101* hsa-miR-101 hsa-miR-101-3p hsa-miR-101-5p Which pairs (if) are the same? Which pairs are the same in sequence?

04 May 2013 6,852 4 View

What's difference between "hsa-let-7a-5p" & "hsa-let-7a-3p"? What do 5p & 3p refer to?

What's difference between "hsa-let-7a-5p" & "hsa-let-7a-3p"? What do 5p & 3p refer to?

04 May 2013 10,014 9 View

How can I ensure that one microRNA doesn't regulate a specific gene or mRNA?

I need some negative data for running my model. These negative data consists of microRNAs and genes that don't interact with each other. How I get this negative data?

04 May 2013 1,754 4 View

how can I convert Fastq to SAM file?

dears: I'm working on chip-seq data. I've downloaded sra format data. to analyze I have to convert them to fastq format and then to SAM file. I made a fastq file but I cant convert it to SAM file?...

11 December 2012 4,215 14 View

What is the state of the drug inside solid lipid nanoparticles (SLNs)?

I am a little confuse with the mechanism of solid lipid nanoparticles (SLNs). The main point of encapsulating drugs into SLNs is because some drugs have low solubility in water. Therefore, SLNs...

01 March 2021 3,703 3 View

How does an antibody have full intact antibody + half antibody?

Hello, I was just wondering how does a antibody have full intact antibody + half antibody? Is it because of the drug conjugation?

28 February 2021 1,577 1 View

MiRNA qpcr problem?

Dear All, mirna primer showing some problem in the melting curve? any idea why? As attached is the melting curve. The forward sequence is obtained from miRBase and reverse primer is universal.

28 February 2021 5,008 4 View

How do I choose contrasts in SPM8?

I am learning how to use SPM for PET and PET-MR analysis, but I haven't found any great resources that explain how contrasts work. I have a series of PET images where our hypothesis argues that...

24 February 2021 1,534 2 View

Can MicroRNA cross the blood brain barrier?

In diseased conditions, many genes and gene products are visible in the bloodstream. So my question is whether we can find traces of microRNA which is involved in disease and disorder in blood serum?

24 February 2021 7,064 3 View

Does anyone have any ideas why drug-resistant malaria is increasing in Southeast Asia even when those drugs are no longer used?

When dealing with bacterial toxins, there are three varieties of microbes that develop in your petri dish: toxic, resistant, and susceptible. Initially, there are only toxic and vulnerable...

21 February 2021 6,084 5 View

What is the most prevalent drug related problem in the developed countries?

Detecting the drug related problems is an important step in the pharmaceutical care plan

21 February 2021 5,421 3 View

Are exogenous molecules transferred between human cells during doubling ?

Hello RG community, I wonderer whether exogenous molecules (e.g. reporter plasmids, miRNAs or other artificial molecules) are transferred between cultured human cells during their doubling ? So,...

21 February 2021 6,633 3 View

What are the potential shell well and atomic solvation parameters for the boron atom?

I have a protein-ligand docking project. The ligand contains boron atoms that are not detected by Autodock software. To solve this problem, it is necessary to introduce the boron atom to...

19 February 2021 1,236 1 View

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19 February 2021 8,647 3 View