How to calculate drugs/compounds similarity?

More Ali Akbar Jamali's questions See All

What are the microRNA-drug interaction databases?

I am looking for databases that contain microRNA-drug interactions. Any suggestions or recommendations?

09 October 2019 5,374 4 View

MicroRNAs in Breast cancer?

I need to get the list of microRNAs involving in breast cancer. is there any review paper, database, online tool, etc.?

06 July 2018 4,772 0 View

Software for Drug and miRNA docking simulation?

I need to study the interaction between some drugs and miRNAs. I was wondering if someone can tell me how can I perform this simulation? Is there any software? or how can I perform this simulation...

05 June 2018 5,895 7 View

How can get 3D structure of my desire protein sequence in PDB format??

I need PDB format of my desire proteins. I have their sequence. how can I get me question solved?

02 March 2016 2,243 1 View

Where & How can I get full 3'-UTR sequences for Bos taurus?

I need full 3'-UTRs for Bos taurus. who knows where I can get this fasta file? please share any link if is possible.

10 November 2014 5,230 0 View

Where can I get validated negative interaction?

I'm in need of experimentally validated microRNA negative interaction. I got validated positive interactions from mirtarbase. But I don't know where to get negative ones. Please share if you have...

03 April 2014 749 1 View

What is the difference between microRNAs with star and without star?

For example what's the difference between these 4 microRNAs? hsa-miR-101* hsa-miR-101 hsa-miR-101-3p hsa-miR-101-5p Which pairs (if) are the same? Which pairs are the same in sequence?

04 May 2013 6,939 4 View

What's difference between "hsa-let-7a-5p" & "hsa-let-7a-3p"? What do 5p & 3p refer to?

04 May 2013 10,086 9 View

How can I ensure that one microRNA doesn't regulate a specific gene or mRNA?

I need some negative data for running my model. These negative data consists of microRNAs and genes that don't interact with each other. How I get this negative data?

04 May 2013 1,830 4 View

how can I convert Fastq to SAM file?

dears: I'm working on chip-seq data. I've downloaded sra format data. to analyze I have to convert them to fastq format and then to SAM file. I made a fastq file but I cant convert it to SAM file?...

11 December 2012 4,331 14 View

How to define an anisotropic material with asymmetric elastic compliance/stiffness matrix in ANSYS APDL?

I need to model an anisotropic material in which the Poisson's ratio ν_12 ≠ ν_21 and so on. Therefore, the elastic compliance matrix wouldn't be a symmetric one. In ANSYS APDL, for TB,ANEL...

09 August 2024 5,048 2 View

Is it true that $\det(V(A))$ may be only $\pm 1$, depending on $n$, for the last symmetric tridiagonal matrix $A$?

One can try to generalize the Vandermonde determinant in the following direction: Let $A$ be any symmetric $n$-order square matrix. Consider its powers' diagonal elements $(A^k)_{ii}$ and...

08 August 2024 6,690 1 View

What precautions should be taken while handling S. aureus enterotoxin Type B in the lab?

I would like to understand potential safety concerns while handling SEB in the lab. Especially while working in animal house facility. Would like to know precautions for handling. Sigma MSDS...

07 August 2024 6,034 3 View

How to understand this crystallographic phenomenon of low temperature crystals in zeolite?

During low-temperature testing, new diffraction peaks that appear could be indicative of several phenomena. In one of our tests, we observed notable new peaks around 40° and 45° in a specific...

06 August 2024 726 3 View

For an in-vitro drug release study, what molecular weight cut-off (MWCO) dialysis bag is required for a 117 kDa protein?

kindly reply me. Thanking you in advance.

05 August 2024 7,727 4 View

Usage of internal standards in LC-MS/MS analysis?

Have you ever seen a LC-MS/MS method uses both internal standards and external standards (in matrix matching purpose) but the concentrations of internal standards are outside the calibration curve...

05 August 2024 3,084 6 View

Request a single Lecture notes for math as detailed as this that I can find in one place?

- The Existence/Uniqueness of Solutions to Higher Order Linear Differential Equations - Higher Order Homogenous Differential Equations - Wronskian Determinants of $n$ Functions - Wronskian...

03 August 2024 2,366 0 View

Tissue homogenization in mouse with FastPrep-24™ 5G - is the D matrix system useful?

I need to lyse and homogenise mouse tissues. So far I have experimented with liver and lung tissue, using matrix D. The liver was completely lysed with 6 repetitions of the standard program, but...

31 July 2024 9,186 0 View

Is it true that science is leaving the era of mathematics and entering the era of matrix mechanics?

We assume this to be true. Science leaves the era of mathematics and enters the era of matrix mechanics and the turning point is the discovery of numerical statistical theory called Cairo...

31 July 2024 3,900 2 View

Where to find a gene list for CRISPRa/i library screening of regulatory factors that affect pathogenic Th17 differentiation in PBMC?

I want to perform a CRISPRa/i library screening for candidate regulatory factors that affect pathogenic Th17 differentiation in PBMC. But I am wondering how to define the size of gene library, so...

31 July 2024 2,150 0 View

Pingjian Ding

Open Babel, a free open-source initiatives, may be used. https://www.nature.com/articles/nprot.2014.151

Aloisia Schmid

I am sorry I don't have the pdf to send, but I found this citation which seems to be right en point. If you need more info, jsut google dissimilarity subsets for compound collections.

Article Dissimilarity-based compound selection techniques