I am trying to crystallize a mesophilic enzyme and had set up screening for conditions by microbatch method. I saw huge structures in many conditions (images attached) after 3 weeks. But when we try to pick it up, they bend and twist and appear gel-like. Also, they did not yield any diffraction pattern. Are these protein crystals? and what optimization should I do? Your inputs will be very valuable
Thanks and regards,
lakshmeesha