Minimum IC50 (mM) FDA Approval Figure?

Joel Subach @Joel-Subach

08 December 2022 0 4K Report

Hello, for the above topic I understand there maybe other variables, however,

in general?

Thanks:)

Badges
Science topic

More Joel Subach's questions See All

What are the research gaps for telematic technologies for road pavements optimization?

what can be the undiscovered benefits of applying telematic technologies for road pavement maintenance, incident reduction and environmental protection?

29 June 2024 7,507 1 View

Why am i getting the human verification when i search for certain topic?

most of the time when i search fo certain topic i found the human verification respond and nothing change there after

19 March 2024 6,870 0 View

How to handle twins in birth order analysis?

Hello! I have a methodological question and I hope someone can help me. I collected data via an online survey with a sample size of 2600 (N = 2600). Initially, I aimed to examine the effect of...

26 February 2024 6,911 4 View

FfTK Calc Bonded Tab ORCA gbw file not recognized INQUIRY?

Hi RG Community I had input all the appropriate files, however, received an Action halted on error! My ORCA generated .gbw QM Output file was not recognized (please see screenshot attached). I...

15 February 2024 2,553 1 View

How long would it take a biofiltratration sysytem in fish culture to complete the nitrogen cycle?

Typically, it is said that biofilter by their nature allow the settling of bacteria beneficial to the treatment of fishwaste. Fish culture though is known for producing high amounts of ammonia in...

28 January 2024 2,398 3 View

Why do eastern European nations seem to have a significantly lower all-cause mortality rate than the UK, Canada, and the U.S.?

From what I can tell by searching the "Your World in Data" website, eastern Europe seems to have an expected lower than average all-cause mortality rate than the western first world nations, who...

04 January 2024 7,066 0 View

Topology Validation Inquiry within an .str File via CGenFF Inquiry?

Hello RG Community:), I have a ligand exhibiting penalties between 10-50 within a .str file generated via a CGenFF, the generated .prm file does not exactly match the ligand atoms nor the closest...

25 December 2023 4,364 1 View

Alphafold Monomer versus MODELLER Oligomer Loop Modeling Inquiry?

Hi I had modelled a heptamer transmembrane protein missing 10-residues within the extracellular loops via MODELLER constraining the known residues as a heptamer (when MODELLER modeled as a monomer...

08 December 2023 4,512 0 View

AlphaFold Multimer Loop Modeling Inquiry?

Hello towards the above topic, I successfully loop-modeled a transmembrane heptamer protein (426-residues per monomer) exhibiting 7-extracellular loops each missing 11-residues via MODELLER via...

03 December 2023 9,528 2 View

Need a simulation tool to generate synthetic data 🙏?

Need a simulation tool to generate synthetic data Specialized engine simulation software (for control and diagnosis) how and what to do 🙏?

16 November 2023 4,128 1 View

How can I calculate IC50 in DPPH test by using graph pad prism software?

How can I calculate IC50 in the DPPH test using graph pad prism software? or suggest a manual method and other software to calculate the IC50 value.

06 August 2024 8,848 3 View

What are the regulatory guidelines to submit a microorganism as Generally Regarded as Safe ?

Give in detail with available literature and website links for submissions

27 June 2024 9,753 1 View

What is the correct method to calculate the IC50 value for the MTT assay?

I had done calculating MTT assay using Slope intercept method - Excel Four parameter logistic regression model-web portal Using Graphpad prism. Among them which one is the best and suitable for...

01 June 2024 2,576 3 View

Calcul IC50 rélatif par graphpad prism 10 ?

Bonjour, 1. Comment déterminer l' IC50 rélatif du test MTT par le GraphPad Prism 10 ? En effet, j'ai un résultat pour la dose maximal utilisée est de 60% de perte de viabilité et non pas à 100...

09 May 2024 5,759 2 View

How to calculate IC50 for different populations have anticancer activity?

How to calculate IC50 for different populations have anticancer activity

26 April 2024 5,066 3 View

Can you help me to find over than 30 Cannabis plant derived molecules with IC50 ?

Hello, I am looking for a series of over 30 molecules derived from the cannabis plant with a specific biological activity and the IC50 values of all the molecules. Could you help me find this...

22 April 2024 9,460 0 View

Discrepancy in Cytotoxicity Assessment of MDA-MB231 Cell Line: Seeking Clarification on IC50 Determination?

I'm currently conducting an experiment on the MDA-MB231 cell line, aiming to assess cytotoxicity using the XTT assay to determine the IC50. Initially, I seeded the cells at a density of 7000 cells...

14 April 2024 1,882 1 View

Can I calculate the IC50 value from the Ellman assay?

Would it be appropriate to compare this value with the IC50 value obtained from the MTT assay? How can I calculate it?

18 March 2024 8,339 1 View

How to calculate and select the treatment dose for combination of two drugs ?

currently, i am working on cancer cells and trying to study the effects in combination. One is a known anticancer drug but the other does not show any anticancer properties however it can reduce...

17 March 2024 9,764 1 View

Fluid mechanics of air embolism and blood leakage through arterial catheterization interventions?

How can I calculate the risk of air embolism or blood leakage when using a microchannel catheter (polyimide, ID ~ 0.015") in femoral arteries, considering the pressure differences and factors like...

07 March 2024 320 0 View