Cu(I)I nanoparticles synthesised through green synthesis route can be good at wound healing

If we add siRNA in to nanoparticles

wii it works for wound healing?

Activating the local innate immune system may be required for effective wound healing.  Forexample: immunomodulators like CpG. Combination of the immunomodulators with NP may help.  

You can look into silver nanoparticles as well. Check the following paper: Tian, Jun, et al. "Topical delivery of silver nanoparticles promotes wound healing." ChemMedChem 2.1 (2007): 129-136.

i read about ZINC OXIDE nanoparticles are also useful for wound healing purpose....

Nanoparticles have been widely used for siRNA, plasmid DNA, and viral gene delivery. The can offer a protective encapsulation before and during the process of (targeted) cellular uptake. Nanoparticle chemistry can also be modified to limit entry into the lysosomal pathway and to increase release into the cytoplasm.

Thanks to all for your valuable suggestions

Wound healing is a process which directly related to angiogenesis. Our group has recently published that Europium oxide nanorods and zinc oxide nanoflowers promote angiogenesis. I strongly believe that these nanoparticles will also work for wound healing. Also, siver nanoparticles also help in healing of wounds.

Yaa sure Mr. Masoud. You can check these following articles:

1. Reactive Oxygen Species Driven Angiogenesis by Inorganic Nanorods.

2. Zinc oxide nanoflowers make new blood vessels

hi thanusha,

till now most of studies revealed that silver nanoparticles are effective in wound healing purposes.

find the links for more information

Silver Nanoparticles as Real Topical Bullets for Wound Healing(http://www.sciencedirect.com/science/article/pii/S1876498312000380)

http://www.nejm.org/doi/full/10.1056/NEJM199909023411006

hope its helpful,

regards

thank you ramesh...

Silver nanoparticles have been used for wound healing

I would love to tell that we are currently checking the mechanism behind the nanoparticle based angiogenesis, which I think may help in wound healing. Interestingly, we have found that there is controlled NO and ROS generation which are promoting angiogenesis.

I completely agree with Dr. Davina Gabriela.

I use a lot of the dressing Acticoat in my practice, and have studied it extensively in clinical trials and in vitriol. Acticoat contains nano-crystalline silver. I am reliably informed that when water is applied to the dressing the nano-crystalline structure gives off silver ions and silver atoms. The silver ions kill bacteria, and the atoms have an anti-inflammatory action. This is certainly the effect that is seen clinically. Unfortunately the silver also is toxic to keratinocytes. Therefore it is a balance between killing bugs and killing keratinocytes.  For example, Acticoat will delay wound healing if used on non infected burns, but is a superb dressing if used on an infected or dirty wound that has a strong potential for infection.

These papers will also be useful

http://pubs.rsc.org/is/content/articlehtml/2014/ra/c4ra07361d

http://pubs.rsc.org/en/content/articlehtml/2014/ra/c4ra02450h

copper I iodide are effective in wound healing.