Depends on the type of analysis you are looking for. Normally, each MD package (Amber, GROMACS, etc.) has its own analysis tools. If the analysis is too specific, you may have to write your own code. I did that a couple of times to study the hydration shell around lanthanide complexes. There is a tool from Professor David Cantu specifically developed for that purpose (doi: 10.1021/acs.jcim.3c00294). I have never used it, but it looks interesting.
Alexandre C. Oliveira Thank you for your insightful response and for sharing the reference to Professor David Cantu's tool.I appreciate your suggestion and will certainly look into it.