I must sadly and repeatedly say that cancer is not caused by mutations and/or deletions at all (please see file; HepG2 fucoidan). Cancer specific marker-proteins are not present in humans. Then, the idea of immuno therapy is absurd.
Since liver cancer changes glycochain structures of cell-surface glycoproteins and glycolipids by adding L-fucose, detection method of glycochain structures may become important (please see files; Aoyagi Fucose, Anticancer Res and HepG2 fucoidan).
By the way, TFR1/ TfR1/Transferrin receptor protein 1/CD71 is not present in my human-liver protein-database made by PDMD (Protein-Direct-Microsequencing-Deciphering) method (please see again file; HepG2 Fucoidan). The reason of this absence of CD71 may be due to species differences. Human liver cells highly express Transferrin.
CD1d, CD5 antigen-like/IgM-associated peptide, CD8-alpha, CD8-beta, CD13, CD14, CD20 antigen-like 7/Membrane-spanning 4-domains subfamily A member 10, CD21, CD29, CD30, CD40, CD44, CD45, CD49b, CD49d, CD51, CD55/Complement decay-accelerating factor, CD56, CD58, CD61, CD88, CD98, CD99, CD103/Integrin alpha-E/HML-1 antigen, CD104, CD107a, CD116/Granulocyte-macrophage colony-stimulating factor receptor alpha chain/GM-CSF-R, CD117, CD127, CD129, CD152, CD154, CD163, CD233/Anion exchange protein 1/Band 3 anion transport proteinSLC4A1, CD243, CD331, and CD332 are present in human protein database at this time.
By the way, Iron/Fe seems to be an important nutrition for humans. Iron-related proteins are searched in my protein database (please see also; JMBT alopecia).
Normal liver (pseudo-liver cancer) has HbA at 27.0 μg/mg tissue protein. This tissue has no Transferrin.
LC tissue (with leprosy) has Transferrin at 37.0, HbA at 21.5, Ferrochelatase, mitochondrial/Heme synthase at 2.4, and Haptoglobin-2 at 2.4 μg/mg tissue protein, respectively.
HCC tissue (with PBC) has Transferrin at 8.4, and HbA at 32.5 μg/mg tissue protein, respectively.
LC tissue (named as No.6) has Transferrin at 26.5, and HbA at 56.0 μg/mg tissue protein, respectively.
HCC tissue(No.6) has Transferrin at 32.6, HbA at 187.0 (18.7%), and Coagulation factor V/Factor V at 5.6 μg/mg tissue protein, respectively.
Hepatoma HepG2 (cultured without fucoidan) has Transferrin at 8.7 μg/mg cell protein.
Healed hepatocyte HepG2 (cultured with fucoidan for 3 days) has Transferrin at 12.6, and Amyloid beta A4 protein/Alzheimer disease amyloid protein at 0.34 μg/mg cell protein, respectively.
Since normal liver (pseudo-liver cancer) has no Transferrin but grows well, Transferrin may be not important for growth. Transferrin seems to be a defending protein against invading microbes.