Let's suppose hsa-miR-320 was found to be deferentially expressed in ESRD (end stage renal disease) - how can we predict its exact gene in the renal cortex?
Hi,
Check the OSDD servers
http://crdd.osdd.net/osddchem/
Hope this hepls.
Regards
miRWalk database provide searching by tissue/metabolic pathway/disease.
you may try mirtarbase
http://mirtarbase.mbc.nctu.edu.tw/
Generally, the collected miRNA-target interactions are validated experimentally by reporter assay, western blot, microarray and next-generation sequencing experiments.
There's one called DIANA TarBase that has experimentally validated miRNA/target gene interactions and the types of experiments they were found in:
http://diana.imis.athena-innovation.gr/DianaTools/index.php?r=tarbase/index
Here's the PubMed link about it, and it's an open-access article:
http://www.ncbi.nlm.nih.gov/pubmed/18957447
You may try miRecords (http://mirecords.biolead.org /) which includes 11 databases (DIANAmicroT, Microinspector, miRanda, MirTarget2, miTarget, NBmiRTar, PicTar, PITA, RNA22, RNAhybrid and TargetScan) for prediction.
http://mirtarbase.mbc.nctu.edu.tw/
Be sure about how updated is the release
Here is a nice paper that may help you to choose a database:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182075/
Targets avialble in miRTarbase, dIANA tools, MirWalk are showed oly targeted gene, but they are not showing any organ specific gene, so is there any database which have data for target organ specific gene.
You may try "mirandb":
http://www.mirandb.ir/
I hope you will find it useful.
http://202.38.126.151/hmdd/mirna/md/ HMDD could be an answer to your query....
there is an update of this data base... please visit http://www.cuilab.cn/hmdd (HMDD2) besides the earlier.
Thanks
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