Globally, colorectal cancer (CRC) is more common in males than in females.

Globocan Men: 23.4 Women: 16.2 Male-to-female ratio 1.4:1.

Lifestyle factors: Higher rates of smoking, alcohol consumption, red/processed meat intake in men. Hormonal influence: Estrogens may have a protective effect in premenopausal women. Screening uptake: In some regions, men are less likely to undergo early screening, leading to more late-stage diagnoses — though this affects mortality more than incidence. Anatomical/tumor biology differences: Higher proportion of rectal and distal colon cancers in men.

Valuable information, with many thanks, Professor Mauricio Zuluaga.

Yes. Colorectal cancer is slightly more common in males than in females, with men having about a 25–30% higher risk. This difference is linked to factors such as lifestyle, diet, hormonal influences, and possibly variations in screening uptake.

Recently, one of the risk factors could be an E. coli population, selected in the bowel environment, producing an oncogenic enterotoxin.

This could be related to different diets between males and females.

slightly higher in men because they have less regular eating habits and higher consumption of alcohol, smoking and red meat which alter the intestinal microbiota