The Phthalates are used as a plasticizer in Plastic products, and it will expose when are used this plastic packed products. These phthalates are migrates form plastic packaging.
one of the major side effect of Phthalates is affecting male reproductive system.
So, It was questioned that..
Any mechanism by which the Phthalates will affect the male reproductive system ? or
Any report that will represent pharmacokinetic/pharmacodynamic or toxicity of Phthalates and its metabolite and its relevance to male reproductive system.
There are assumed to be multiple mechanism, though one of the important mechanism is activation of the fas present in the surface of sertoli cell by increasing expression of fas ligand.
for more details, you can refer to the review (figure 4 ). Here is the link
https://www.researchgate.net/publication/308910902_Review_on_crosstalk_and_common_mechanisms_of_endocrine_disruptors_Scaffolding_to_improve_PBPKPD_model_of_EDC_mixture
Article Review on crosstalk and common mechanisms of endocrine disru...
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