Kashyap Thummar

11 Questions 19 Answers 0 Followers

Questions related from Kashyap Thummar

Is there any acceptable limit/value of Phthalate metabolites in human urine?

I am working on "Prevalence of Phthalate Metabolite in human Urine sample using Chromatographic method" I have selected and estimated mainly four metabolites, 1) Mono methyl Phthalate (MMP), 2)...

30 April 2018 862 1 View

How phthalates are affecting male reproductive system?

The Phthalates are used as a plasticizer in Plastic products, and it will expose when are used this plastic packed products. These phthalates are migrates form plastic packaging. one of the major...

25 August 2017 6,310 2 View

What is the safety level of extractable and leachables ?

Through my research some extractables and leachables were found from the pharmaceutical products by LC-MS/MS. So, How can I correlate toxicological assessment, If Safety level are there for Human...

02 June 2017 5,103 8 View

How to determine the residual formalin after sanitizing water pipe line in Hospital?

In Hospital, specifically Kidney hospital, RO water was used for the cleaning of many equipment that could be reuse after cleaning. The RO water line would be sanitize with formalin to prevent...

24 April 2017 2,810 6 View

How content uniformity was performed in the ointment or Gels ?

In various Pharmacopoeia, It was much discussed about tablet and capsule and others, but less discussed the content uniformity of semi solids like ointment and Gels. For example, Single component...

24 February 2017 1,620 3 View

Which are the extractables and leachables standards are available to carry out research in the field of pharmaceutical packaging (Plastic Container)?

apart from Bisphenol-AStyrenevinyl chlorideDiethylene glycolDi-2 ethylhexyl phthalateDimethyl phthalateDiethyl phthalate

19 November 2015 3,120 2 View

Any suggestion, for getting so much higher blood drug concentration of Lamotrigine by LC-MS/MS in epileptic patients?

I have developed bioanalytical method for estimation of Lamotrigine in human plasma using LC-MS/MS and now I am going to apply my method to Therapeutic drug monitoring and Pharmacokinetics in...

16 May 2015 5,798 4 View

What is the precursor ion peak in Adapalene?

I am doing the research on characterization of impurities in adapalene by forced degradation (acid, alkali, oxidation etc....), I have getting the separation of the several impurities by HPTLC...

28 January 2015 4,100 5 View

I am not getting Precursor/Product ion of Diacylgymnemic acid using LC-ESI-MS/MS after so many trials. Any suggestions?

Whatever precursor/product ions get it will not be repeated the next day. So, I can't finalize the method.

01 December 2014 3,184 6 View

Can anyone explain the fragmentation pattern of Pamabrom in MS??

I worked in Bioanalytical method development and validation of two drugs, Paracetamol (PCM) and Pamabrom (PAMA), the multiple reaction monitoring (MRM) of the transitions m/z 152.10→110.10 for PCM...

26 September 2014 9,393 2 View

What SPE cartridge and protocol are ideal for extracting both polar and non-polar compounds from large (500 mL) aqueous samples?

I'm working on extracting a wide variety of polar and non-polar compounds (antibiotics) from large aqueous samples (500 mL volume). What type of solid-phase extraction (SPE) cartridge would be...

01 January 1970 1,709 3 View