People use Dextran sodium sulphate to induce colitis, as a observation colon length shorten. What is actual changes happened during treatment resulting in shorter length of colon
DSS is too toxic to colon epithelial linings and induce epithelial damage thereby reducing the length. Basically, It causes a loss of surface epithelium, enabling luminal microbes and their metabolites enter the lamina propria and induce an inflammatory response.